老年男性急性冠脉综合征患者血清瘦素水平的变化及临床意义

目的探讨老年男性急性冠脉综合征(ACS)患者血清瘦素(LP)水平的变化及临床意义。方法采用酶联免疫法测定老年男性急性心肌梗死(n=30,AMI组)和不稳定型心绞痛(n=30,UA组)患者血清LP水平,另设30例健康体检者作为对照组,分析血清LP与病情严重程度的关系。结果AMI组、UA组患者血清LP水平较正常对照组显著升高(P<0.01);AMI组血清LP浓度明显高于UA组(P<0.05)。ACS患者LP水平分别与BMI、TG、SBP、DBP呈正相关,与ISI呈负相关(P<0.05或P<0.01)。结论血清LP是老年男性ACS重要的危险因素及预测因子,而且与病情严重程度呈正相关。

The clinical significance of serum leptin levels in elderly patients with acute coronary syndrome

Objective To investigate the changes of serum leptin(LP) levels and their clinical significance in elderly patients with acute coronary syndrome (ACS).Methods Serum LP levels were detected in male patients with acute myocardial infarction(AMI,n=30) and unstable angina (UA,n=30).30 healthy subjects were enrolled as control group,the relationship between serum LP levels and severity of ACS were analysed.Results As compared with control group, there was a significant increase in serum LP levels in AMI and UA group (P<0.01).The serum LP levels in AMI group were significantly higher than those in UA group (P<0.01).The serum LP levels in ACS patients were positively correlated with BMI、TG、SBP、DBP and negatively correlated with ISI (P<0.05 or P<0.01).Conclusion The serum LP level is an important risk and predictive factor for elderly male patients with ACS,which is positively correlated with the severity of ACS.