宫颈细胞TBS＋DNA倍体定量检测在宫颈病变中的应用

目的：通过对宫颈细胞TBS＋DNA倍体定量检测，及早发现宫颈病变，阻断宫颈癌的发生。方法：对妇科门诊就诊的1000例妇女进行宫颈细胞TBS＋DNA倍体定量检测，阳性患者再做宫颈活检。诊断标准采用TBS分类系统。结果：1000例妇女宫颈刮片标本，TBS＋DNA倍体定量检测阳性53例，阳性率为5．3％，其中不典型腺细胞（AGCUS）2例。低度鳞状上皮内病变（LSIL）40例，高度鳞状上皮内病变（HSIL）9例，鳞状细胞癌（SCC）2例。53例阳性者进行宫颈活检，其中轻度不典型腺上皮增生2例，CINⅠ39例，CINⅡ7例，CINⅢ3例，SCC2例。宫颈活检对TBS＋DNA倍体检测提供的阳性病变加以确诊。30～40岁年龄阶段是CIN的高发年龄，发病率为56．6％（30／53）。结论：宫颈细胞TBS＋DNA倍体定量测定与病理组织学有一定的相关性。TBS＋DNA倍体定量测定作为无创伤检测是门诊筛查子宫颈癌的有效方法。对年轻妇女应特别关注宫颈癌的门诊筛查工作。

The purpose of cervical cells by TBS + DNA quantitative detection in cervical lesions

Objective:The purpose of cervical cells by TBS + DNA ploidy quantitative detection, early detection of cervi-cal lesions, blocked the occurrence of cervical cancer. Methods: Gynecology clinics of 1 000 eases of cervical cells, women in TBS + DNA ploidy quantitative tests in patients with positive cervical biopsy done. Diagnostic criteria for the use of TBS classification systems. Results: 1 000 cases of women in cervical serape specimens films, TBS + DNA ploidy in 53 cases of positive quantitative detection, the positive rate was 5.3%, in which atypical glandular cells (AGCUS) 2 cases, low-grade squamous intraepithelial lesion (LSIL) 40 cases, a high degree of squamous intraepithelial lesion (HSIL) 9 cases of squamous cell carcinoma (SCC) 2 cases. Positive for 53 eases of cervical biopsy, which mild atypical glandular hyper-plasia and 2 eases, CIN Ⅰ 39 cases, CIN Ⅱ 7 cases, CIN Ⅲ 3 cases, scc 2 cases. Cervical biopsy of TBS + DNA ploidy provide positive detection of lesions to be diagnosed. Ages 30-40 years of age is the age of high incidence of CIN, the probability was 30/53 (56.6%). Conclusion:Cervical cells TBS+DNA ploidy and quantitative determination of some histological correlation. TBS+DNA quantitative determination of ploidy as a non-invasive detection of out-patient screening is an effective method for cervical cancer. Screening for cervical cancer patient to pay special attention to young women.