| 骨髓间充质干细胞向纤维软骨细胞表型诱导分化的实验研究 |
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| 引用本文： | 蔡贵泉,崔一民,陈晓东. 骨髓间充质干细胞向纤维软骨细胞表型诱导分化的实验研究[J]. 中国神经再生研究, 2010, 14(2) |
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| 作者姓名： | 蔡贵泉 崔一民 陈晓东 |
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| 作者单位： | 上海交通大学医学院附属新华医院骨科，上海市200092,上海交通大学医学院附属新华医院骨科，上海市200092,上海交通大学医学院附属新华医院骨科，上海市200092 |
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| 摘 要： | 人膝关节半月板损伤是骨科的常见病，随着对半月板功能及半月板切除后并发症认识的不断深入，人们意识到修复和保留半月板功能的重要性[1、2]。组织工程技术使修复甚至再造半月板成为可能。组织工程化半月板的重要条件之一是必须获得大量的有功能和活力的纤维软骨细胞，而骨髓间充质干细胞是存在于骨髓内的一种具有多向分化潜能的成体干细胞，可定向诱导分化为骨[3]、软骨[4]、肌腱[5]、脂肪[6]等细胞系，可在体外大量培养扩增，有可能成为组织工程较为理想的种子细胞来源。我们的实验旨在建立一种骨髓间充质干细胞向纤维软骨细胞表型分化的体外培养体系，对体外诱导培养不同时期的骨髓间充质干细胞进行连续鉴定，从而为骨髓间充质干细胞作为半月板组织工程的种子细胞来源提供理论和实验依据。
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| 关 键 词： | 骨髓间充质干细胞；纤维软骨细胞；诱导；分化 |
| 收稿时间： | 2009-06-11 |
| 修稿时间： | 2009-07-23 |
The experimental study of differentiation of bone marrow mesenchymal stem cells into fibrochondrocyte phenotype in vitro |
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| Cai Gui-quan,Cui Yi-min and Chen Xiao-dong. The experimental study of differentiation of bone marrow mesenchymal stem cells into fibrochondrocyte phenotype in vitro[J]. Neural Regeneration Research, 2010, 14(2) |
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| Authors: | Cai Gui-quan Cui Yi-min Chen Xiao-dong |
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| Affiliation: | Department of Orthopaedics, Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai 200092, China,Department of Orthopaedics, Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai 200092, China,Department of Orthopaedics, Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai 200092, China |
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| Abstract: | The meniscus has limited ability to repair itself after injured. Tissue engineering affords a new way to meniscus repair. Seed cells is one of the important factors for tissue-engineered meniscus. Bone marrow mesenchymal stem cells(BMSCs) which possess the potential of multiple differentiations can be an ideal seed cells in meniscus tissue engineering. |
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