米诺环素治疗解脲支原体感染性精液不液化症的临床研究

目的探讨米诺环素（minocycline）对解脲支原体（UU）感染性精液不液化症的治疗效果。方法通过对198例男性UU感染性精液不液化症分组进行治疗观察，探讨米诺环素治疗精液不液化症的疗效、UU转阴率和迟缓液化复发率。结果UU转阴率米诺环素治疗组为90．6％（77／85），高于罗红霉素治疗组60．9％（39／64）]（P〈0．01）。3疗程（6周）后1h内精液完全液化率米诺环素治疗组为87．1％（74／85）高于罗红霉素组60．9％（39／64）]和安慰剂组4．1％（2／49）]（P〈0．01）；半年后精液液化迟缓复发率米诺环素治疗组为16．2％（12／74）低于安慰剂组100．0％（2／2）（P0．05），与罗红霉素组28．2％（11／39）比较，差异无显著性（P〉0．05）。结论米诺环素治疗解脲支原体感染性精液不液化症疗效显著，且不易耐药、复发率低，值得推荐。

Clinical study on semen delayed liquefaction caused by ureaplasma urealyticum infection treated with minocycline

Objective To elucidate the treatment of ureaplasma urealyticum(UU) infectious semen delayed liquefaction with minocycline. Methods One hundred ninety eight cases of semen delayed liquefaction patients with UU infections were treated with minocycline and roxithromycin for 6 weeks. The change of UU detection and semen liquefaction were compared before and after thetreatment. Results Roxithromycin was effective in 39 cases (60.9 %) and minocycline 77 cases (90.6 %). After treatment for 6 weeks,87.1 % of the semen samples in the minocycline groups was liquefied, significantly higher than other two groups (P<0.01). After treatment for six months,the rate of semen delayed liquefaction in the minocycline group(16.2 %) was lower than control groups treated with amylo (100.0 %,P<0.05) ,but had no difference when compared with the roxithromycin group(28.2 %,P>0.05). Conclusion WTBMinocycline is effectivein treating cases with UU infectious semen delayed liquefaction.