| 精子蛋白17的研究进展 |
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| 引用本文： | 张玲,李芳秋. 精子蛋白17的研究进展[J]. 中华男科学杂志, 2004, 10(4): 295-297,301 |
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| 作者姓名： | 张玲 李芳秋 |
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| 作者单位： | 南京军区南京总医院全军医学检验中心,江苏,南京,210002 |
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| 摘 要： | 精子蛋白 17(Sp17)为一种睾丸组织特异性蛋白 ,参与精子的顶体反应。然而 ,近年来发现Sp17在正常非睾丸组织和肿瘤组织也有表达。它作为一种免疫避孕的候选抗原以及肿瘤免疫治疗的理想靶分子倍受关注。本文就Sp17的特性、表达与分布、生理学功能及临床研究的新进展进行了综述。
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| 关 键 词： | 精子蛋白17 免疫避孕 肿瘤免疫治疗 |
| 文章编号： | 1009-3591(2004)04-0295-04 |
| 修稿时间： | 2003-08-13 |
Advances in the Research of Sperm Protein 17 |
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| Zhang Ling,Li FangqiuCenter of Medical Laboratory Science of PLA,Nanjing General Hospital of Nanjing Command,Nanjing,Jiangsu ,China. Advances in the Research of Sperm Protein 17[J]. National journal of andrology, 2004, 10(4): 295-297,301 |
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| Authors: | Zhang Ling Li FangqiuCenter of Medical Laboratory Science of PLA Nanjing General Hospital of Nanjing Command Nanjing Jiangsu China |
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| Affiliation: | Center of Medical Laboratory Science of PLA, Nanjing General Hospital of Nanjing Command, Nanjing, Jiangsu 210002, China. |
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| Abstract: | Sperm protein 17 (Sp17) is a testis-specific protein involved in acrosome reaction in spermatozoa. However, the Sp17 gene has been recently detected in normal non-testis tissues and malignant neoplasias. Therefore Sp17 may be a potential target for immunocontraception and a suitable target for tumor immunotherapy. This paper reviews the advances in the protein characterization, expression and distribution, and biological function of Sp17 and its clinical research. |
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| Keywords: | sperm protein 17 immunocontraception tumor immunotherapy |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
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