| p53 CD44V6及nm23/NDPK在非小细胞肺癌中表达的相关性分析 |
| |
| 引用本文： | 纪远中,聂卫,张志尧,戈以椿,匡朴,李德华,王士贤. p53 CD44V6及nm23/NDPK在非小细胞肺癌中表达的相关性分析[J]. 中国肿瘤临床, 2005, 32(10): 561-563 |
| |
| 作者姓名： | 纪远中 聂卫 张志尧 戈以椿 匡朴 李德华 王士贤 |
| |
| 作者单位： | 1. 天津市医药科学研究所,天津市,300020
2. 天津市胸科医院 |
| |
| 基金项目： | 天津市卫生局科技基金资助(编号:021103004) |
| |
| 摘 要： | 目的:探讨非小细胞肺癌(NSCLC)中p53、CD44V6及nm23/NDPK表达的相关性及预后意义。方法:采用免疫组织化学SP法对69例NSCLC组织中p53、CD44V6及nm23/NDPK进行检测。结果:p53、CD44V6及nm23/NDPK的表达与NSCLC患者的临床分期(P<0.05,P<0.01)、淋巴结转移(P<0.05,P<0.01)及生存率(P<0.05)密切相关。p53、CD44V6表达与nm23/NDPK在NSCLC中的表达呈明显负相关(P<0.01)。结论:联合检测NSCLC中p53、CD44V6及nm23/NDPK的表达对于判断预后和指导治疗可能具有实用价值。
|
| 关 键 词： | 非小细胞肺癌p53 CD44V6 nm23／NDPK 预后 |
| 文章编号： | 1000-8179(2005)10-0561-03 |
Relationship between Expression of p53, CD44V6 and nm23/NDPK in Non-small Cell Lung Cancer |
| |
| Ji Yuanzhong Nie Wei Zhang Zhi-yao et alThe Institute Of Pharmaceutical and Medical Science Of Tianjin,Tianjin. Relationship between Expression of p53, CD44V6 and nm23/NDPK in Non-small Cell Lung Cancer[J]. Chinese Journal of Clinical Oncology, 2005, 32(10): 561-563 |
| |
| Authors: | Ji Yuanzhong Nie Wei Zhang Zhi-yao et alThe Institute Of Pharmaceutical Medical Science Of Tianjin Tianjin |
| |
| Abstract: | Objective: This study was designed to investigate the expression of p53,nm23/NDPK and CD44V6 and their correlations in non-small cell lung cancer (NSCLC). Methods: The expression of p53, CD44V6 and nm23/NDPK was immunohistchemically detected using SP methods in 69 cases with NSCLC. Results: The expression of p53, CD44V6 and nm23/NDPK was significantly related with the staging of the disease (P<0.05, P<0.01), the lymph node involvement ratio (P<0.05, P<0.01) and postoperative survival (P<0.05). Conclusion: Combined detection on the expression of p53, CD44V6 and nm23/NDPK in NSCLC may has the practical value in prognosis of the patients. |
| |
| Keywords: | Non-small cell lung cancer p53 CD44V6 nm23/NDPK Prognosis |
| 本文献已被 CNKI 万方数据 等数据库收录！ |
