| 国产环孢素A微乳胶囊血药浓度监测指标C2与C0的比较 |
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| 引用本文： | 钱方,王海,朱有华,缪海均,邓渝林,刘皋林,王亚伟,郑军华.国产环孢素A微乳胶囊血药浓度监测指标C2与C0的比较[J].中华器官移植杂志,2003,24(5):281-283. |
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| 作者姓名： | 钱方 王海 朱有华 缪海均 邓渝林 刘皋林 王亚伟 郑军华 |
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| 作者单位： | 1. 200003,上海,第二军医大学附属长征医院药学部
2. 200003,上海,第二军医大学附属长征医院肾移植中心 |
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| 摘 要： | 目的 探讨血中环孢素A(CsA)浓度的监测。方法 采用荧光偏振免疫测定法 (FPIA)测定 17例肾移植患者服用国产CsA微乳胶囊后不同时间的血药浓度 ,3P87药代动力学程序处理血药浓度 时间数据。结果 服药后 2h的浓度 (C2 )与 0～ 12h曲线下面积和 0～ 4h曲线下面积之间的相关性优于服药即刻浓度 (C0 ,P <0 .0 5 )。结论 对于服用CsA微乳胶囊者 ,根据C2 来调整CsA的用量 ,较C0 更有效、更安全。
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| 关 键 词： | 环孢素A 微乳胶囊 血药浓度 荧光偏振免疫测定法 药物代谢动力学 |
Comparison between C2 and C0 as a monitoring tool for domestic cyclosporin A microemulsion capsule |
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| QIAN Fang,WANG Hai,ZHU You-hua,et al..Comparison between C2 and C0 as a monitoring tool for domestic cyclosporin A microemulsion capsule[J].Chinese Journal of Organ Transplantation,2003,24(5):281-283. |
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| Authors: | QIAN Fang WANG Hai ZHU You-hua |
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| Institution: | QIAN Fang,WANG Hai,ZHU You-hua,et al. Changzheng Hospital,The Second Military Medical University,Shanghai 200003,China |
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| Abstract: | Objective To testify the possibility that two-hour concentration (C_2) substituting for the target concentration (C_0) is used to be a monitoring tool for CsA. Method The whole blood concentrations of CsA having taken orally in 17 renal transplant patients were measured by FPIA. The data of concentration-time was processed by 3P87 pharmacokinetic program. Results The correlation between C_2 values and AUC_ 0-4 , or AUC_ 0-12 was both more excellent than C_0( P < 0.05 ). Conclusion For those taking domestic cyclosporin A microemulsion capsule, C_2 as a surrogate monitoring tool to adjust the dosage of CsA is more effective and safe than C_0. |
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| Keywords: | Cyclosporine Drug monitoring |
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