| 辛伐他汀对体外成骨细胞、破骨细胞的影响 |
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| 引用本文： | 刘志祥,崔维顶,李玉前,李宏斌,李翔.辛伐他汀对体外成骨细胞、破骨细胞的影响[J].江苏医药,2009,35(11). |
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| 作者姓名： | 刘志祥 崔维顶 李玉前 李宏斌 李翔 |
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| 作者单位： | 1. 南通市第三人民医院骨科,226000
2. 南京医科大学第一附属医院骨科 |
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| 摘 要： | 目的 探讨辛伐他汀对体外培养成骨细胞、破骨细胞的影响.方法 分离SD大鼠成骨细胞、破骨细胞,体外培养时给予辛伐他汀刺激,观察药物对成骨细胞增殖率和碱性磷酸酶以及骨细胞骨吸收的影响.结果 辛伐他汀10~(-6)～10~(-9)mol/L对碱性磷酸酶的分泌有明显促进作用,10~(-6)～10~(-8)mol/L的辛伐他汀既促进成骨细胞的增殖,又抑制破骨细胞的骨吸收.结论 辛伐他汀在体外促进骨形成、抑制骨吸收,有望成为治疗骨质疏松的约物.
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| 关 键 词： | 辛伐他汀 成骨细胞 破骨细胞 |
Effect of simvastatin on osteoblasts, usteoclasts cultured in vitro |
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| Abstract: | Objective To study the effect of simvastatin on osteoblasts, osteoclasts cultured in vitro. Methods Osteoblasts, osteoclasts isolated from SD rats were cultured and stimulated with simvastatin in vitro. The proliferation ratio and alkaline phosphatase(ALP) activity of osteoblasts were assessed and bone absorption activity of osteoclasts was detected. Results Simvastatin 10~(-6)～10~(-9)mol/L markedly stimulated ALP absorption of osteoblasts. Simvastatin 10~(-6)～ 10~(-6) mol/L not only promoted proliferation of osteoblasts but also inhibited bone absorption activity of osteoclasts. Conclusion Simvastatin can promote bone formation and inhibit bone resorption in vitro and could be used for treating osteoporosis in the future. |
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| Keywords: | Simvastatin Osteoblasts Osteoclasts |
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