| 正交设计法优选莲子心微囊的制备工艺 |
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| 引用本文： | 袁小红,骆梅娟.正交设计法优选莲子心微囊的制备工艺[J].中国药房,2006,17(21):1673-1675. |
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| 作者姓名： | 袁小红 骆梅娟 |
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| 作者单位： | 广州中医药大学第二临床医学院,广州市,510120 |
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| 基金项目： | 广东省中医药管理局科研项目 |
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| 摘 要： | 目的:优选莲子心微囊的制备工艺。方法:采用正交设计法对莲子心微囊的制备工艺进行研究,以微囊得率、包封率和载药量为指标,考察药液与明胶溶液的比例、液体石蜡与明胶溶液的比例、80℃时的搅拌时间、明胶浓度等因素对微囊制备工艺的影响。结果:最佳的制备工艺为采用30%的明胶溶液,80℃时搅拌20min,药液与明胶溶液的比例4∶10,液体石蜡与明胶溶液的比例6∶1。结论:优选出的制备工艺经验证可行、可靠。
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| 关 键 词： | 莲子心微囊 正交试验法 制备工艺 |
| 文章编号： | 1001-0408(2006)21-1673-03 |
| 收稿时间： | 03 22 2006 12:00AM |
| 修稿时间： | 05 19 2006 12:00AM |
Study of the Preparation Technique of Plumula Nelumbinis Microcapsules with Orthogonal Design |
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| YUAN Xiaohong,LUO Meijuan.Study of the Preparation Technique of Plumula Nelumbinis Microcapsules with Orthogonal Design[J].China Pharmacy,2006,17(21):1673-1675. |
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| Authors: | YUAN Xiaohong LUO Meijuan |
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| Institution: | The Second College of Clinical Medicine of Guangzhou University of TCM, Guangzhou, 510120, China |
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| Abstract: | OBJECTIVE: To optimize the preparation technique of plumula nelumbinis microcapsule.METHODS: The method of orthogonal design was used to study the preparation technique of plumula nelumbinis microcapsule,yield rate of microcapsule,the encapsulation rate and total alkaloids content of inclusion microcapsule were adopted as indexes,factors of proportions of extraction of plumula nelumbinis to gelatin solution and liquid paraffin to gelatin solution stirring time at 80℃,concentration of gelatin solution were evaluated to see their effects on preparation process.RESULTS: Optimal parameters were 30% gelatin solution,stirring for 20 minutes at 80℃,a proportion of 4∶ 10 for extraction of plumula nelumbinis to gelatin solution and other proportion of 6∶ 1 for liquid paraffin to gelatin solution.CONCLUSION: The optimal preparation technique is satisfactor and reliable by test and verify. |
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| Keywords: | Plumula nelumbinis microcapsule Orthogonal test Preparation technology |
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