| 促渗剂Azone对几种药物透皮速率的影响 |
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| 引用本文： | 沈子龙,徐进宜,蔺胜照,郭素珍. 促渗剂Azone对几种药物透皮速率的影响[J]. 中国药理学通报, 1989, 0(1) |
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| 作者姓名： | 沈子龙 徐进宜 蔺胜照 郭素珍 |
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| 作者单位： | 中国药科大学药理教研室 南京(沈子龙，徐进宜，蔺胜照)，中国药科大学药理教研室 南京(郭素珍) |
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| 摘 要： | Azone(氮酮)是目前国内外所应用的最好的药物透皮吸收促渗剂之一。本文用~3H-Azone作示踪剂,以离体皮肤体外流通扩散室法,研究了国产Azone对α-细辛醚、硝烟酯和硝酸甘油贴剂中药物渗透速率的影响。实验结果表明,Azone能显著增加上述三种药物的渗透速率,在Azone含量为4.8％时,硝烟酯、硝酸甘油和α-细辛醚的渗透速率分别增加133.7％、82.1％和34.5％,而且增渗作用持久。
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| 关 键 词： | Azone 透皮吸收 透皮促渗剂 硝酸甘油 硝烟酯 α—细辛醚 放射性示踪剂 |
STUDY ON EFFECT OF SKIN PENETRATION ENHANCER AZONE ON THE PENETRATION OF SEVERAL DRUGS THROUGH SKIN |
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| Shen Zilong,Xu Jinyi,Lin Shengzhao Guo Suzhen. STUDY ON EFFECT OF SKIN PENETRATION ENHANCER AZONE ON THE PENETRATION OF SEVERAL DRUGS THROUGH SKIN[J]. Chinese Pharmacological Bulletin, 1989, 0(1) |
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| Authors: | Shen Zilong Xu Jinyi Lin Shengzhao Guo Suzhen |
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| Abstract: | Azone ( 1桪odeylazacyclohenptan-2-one) is one of the best skin penetration enhancers. It can increase the permeability of skin for some hydrophobic compounds, so that it is possible to be admi-nistrated through skin. The effects of Azone on permeability of skin of a-Asarone, Nicorandil and Nitroglycerin were studied by flow through diffusion cell with radioactivity tracer.The results showed that the different concentrations of Azone gave different enhancement. The penetration of the 3 drugs was enhanced about 1-fold by<10.3% Azone in the vehicle as compared with penetration in the same vihicle without it. |
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| Keywords: | Azone Skin penetration enhancer Nitroglycerin Nicorandil a-Asarone Radioactivity tracer |
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