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| 食管癌患者血清IL-2和IL-18测定和意义 | |
| 引用本文： | 李林均,陈元,李瑞超,陆绪军.食管癌患者血清IL-2和IL-18测定和意义[J].中国民康医学,2007,19(7):260-261. |
| 作者姓名： | 李林均 陈元 李瑞超 陆绪军 |
| 作者单位： | 1. 华中科技大学同济医学院附属同济医院肿瘤科,湖北,武汉,430030;湖北郧阳医学院附属十堰市人民医院 2. 华中科技大学同济医学院附属同济医院肿瘤科,湖北,武汉,430030 3. 湖北十堰市界牌社区卫生站 |
| 摘 要： | 目的：IL-2和IL-18在肿瘤的免疫中的作用。方法：本研究使用ELISA法检测了45名食管癌患者和30名健康志愿者的外周血IL-2和IL—18水平。结果：食管癌患者的血清IL-2水平显著低于健康志愿者（P〈0．05）与之相反食管癌患者的血清IL—18水平高于健康志愿者（P〈0．05），并且随着食管癌的进展，食管癌患者的血清IL-2水平降低（P〈0．05）而IL-18升高（P〈0．05）。结论：血清IL-2和IL—18的水平可能与食管癌的发生发展有关，并可反映食管癌的进展。 |
| 关 键 词： | 食管癌IL-2 IL-18 |
| 收稿时间： | 2006-10-31 |
Esophagus cancer patient blood serum IL - 2 and IL - 18 determination and significance |
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| LI Lin-jun, CHEN Yuan, LI Rui -chao, et al.Esophagus cancer patient blood serum IL - 2 and IL - 18 determination and significance[J].medical journal of chinese peoples health,2007,19(7):260-261. | |
| Authors: | LI Lin-jun CHEN Yuan LI Rui -chao |
| Abstract: | Objective:Interleukin IL-2 and IL-18 participate in tumor immunology.Methods:Peripheral blood samples were obtained from 30 healthy volunteers and from 45 patients with esophageal carcinoma.IL-2 and IL-18 levels were determined in each serum sample by enzyme-linked immunosorbent assay.Results: Mean serum IL-18 levels was significantly higher and the serum IL-2 levels was significantly lower in patients with esophageal carcinoma compared with healthy volunteers(P<0.05).Mean IL-18 levels were increased in patients and mean IL-2 levels were decreased as the pathologic stage progressed.Increasing IL-18 levels and decreased IL-2 levels correlated with tumor growth and progression.Conclusions: Serum IL-2 and IL-18 levels might correlate with a certain depth of invasion and might be useful tumor markers in patients with esophageal carcinoma. |
| Keywords: | Esophageal carcinoma IL-2 IL- 18 |
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