| 中国汉族人CYP2J2基因外显子8等位基因多态性研究 |
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| 引用本文： | 钟强,郑智,朱智慧,汪道文. 中国汉族人CYP2J2基因外显子8等位基因多态性研究[J]. 华中科技大学学报(医学版), 2004, 33(2): 183-185 |
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| 作者姓名： | 钟强 郑智 朱智慧 汪道文 |
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| 作者单位： | 1. 华中科技大学同济医学院附属同济医院内科心血管研究室,武汉,430030
2. 华中科技大学同济医学院附属同济医院急诊科,武汉,430030 |
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| 基金项目： | 国家“ 973”重点基础研究发展规划项目(No .G2 0 0 0 0 5 6 90 1) |
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| 摘 要： | 目的：探讨中国汉族人CYP2J2基因外显子8等位基因是否存在基因多态性改变及其与原发性高血压的关系。方法：采用聚合酶链反应(PCR)和限制性片段分析。随机对150例汉族健康体检者及150例汉族原发性高血压患者进行CYP2J2基因外显子8位点进行多态性分析。结果：300例均为野生型，未发现杂合子或纯合子。结论：未发现中国汉族人CYP2J2基因外显子8等位基因突变，中国汉族人高血压可能与CYP2J2基因外显子8等位基因突变导致的氨基酸改变引起的AA代谢异常无关。
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| 关 键 词： | 中国汉族人群 CYP2J2基因 基因多态性 细胞色素P450 高血压 氨基酸 |
| 修稿时间： | 2003-07-24 |
Polymorphism of Exon 8 in CYP2J2 Gene in Chinese Han Population |
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| Zhong Qiang ,Zheng Zhi ,Zhu Zhihui et al. Polymorphism of Exon 8 in CYP2J2 Gene in Chinese Han Population[J]. Journal of Huazhong University of Science and Technology(Health Sciences), 2004, 33(2): 183-185 |
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| Authors: | Zhong Qiang Zheng Zhi Zhu Zhihui et al |
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| Affiliation: | Zhong Qiang 1,Zheng Zhi 2,Zhu Zhihui 1 et al 1 Department of Cardiology,Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430030 2 Department of Emergency,Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430030 |
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| Abstract: | Objective To investigate the changes in Exon 8 polymorphism of CYP2J2 gene and their relation with essential hypertension (EH) in Chinese Han population. Methods Exon 8 polymorphism of CYP2J2 gene was analyzed in 150 EH patients and 150 normotension (NT) people by using polymerase chain reaction (PCR) and restriction enzyme method. Results 150 EH patients and 150 NT people were all wild type, no heterogenotes and homogenotes. Conclusion No Exon 8 polymorphism of CYP2J2 gene in Chinese Han population was discovered. It may be concluded that EH is irrelevant to changes of amino acid that result from mutation of Exon 8 in CYP2J2 gene. |
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| Keywords: | cytochrome P450 2J2 gene polymorphism hypertension |
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