Lack of alpha-adrenoreceptor binding of [125I]BE2254 to rat basilar artery membranes |
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Authors: | G D Silverberg T O Neild A Adams B Jarrott |
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Affiliation: | 1. Dept. of Physiology, Monash University, Clayton, Victoria 3168 Australia;1. Clinical Pharmacology and Therapeutics Unit, University of Melbourne, Austin Hospital, Heidelberg, Victoria 3084 Australia |
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Abstract: | Rat basilar arteries do not contain classical alpha- or beta-adrenoreceptors as assessed by electrophysiological techniques even though these arteries are innervated by catecholamine-containing perivascular nerves. These arteries were therefore examined for their ability to selectively bind an alpha-adrenoceptor radioligand, [125I]BE2254 (2/beta/4-hydroxyphenyl)-ethylaminomethyl)-tetralone). For comparison, rat tail arteries were also studied as these are known to contain functional alpha-adrenoreceptors. It was found that basilar artery membranes had only one-third of the specific binding of tail artery membranes and this finding collaborates the electrophysiological data. |
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Keywords: | To whom correspondence should be addressed. |
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