| 冠心病患者血管紧张素转换酶基因多态性及其与血清血管紧张素转换酶水平的关系 |
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| 引用本文： | 谈红,张国元,尤乃祯,黄超,刘建平. 冠心病患者血管紧张素转换酶基因多态性及其与血清血管紧张素转换酶水平的关系[J]. 中国动脉硬化杂志, 1998, 6(2): 134-136 |
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| 作者姓名： | 谈红 张国元 尤乃祯 黄超 刘建平 |
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| 作者单位： | 济南军区总医院内科!济南250031(谈红，尤乃祯，刘建平)，上海长征医院心内科!上海200003(张国元)，上海长征医院临床免疫中心!上海200003(黄超) |
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| 摘 要： | 为研究冠心病患者血管紧张素转换酶（ACE）基因插入／缺失（I／D）多态性分布及其与血清ACE水平的相关性，应用多聚酶链反应方法测定了61例冠心病患者和63例健康人群的ACE基因I／D多态性，并采用微量比色法测定其血清ACE水平。结果发现，冠心病患者ACE基因DD型出现频率显著高于对照组，且DD基因型者具有较高的血清ACE水平。提示ACE基因I／D多态性与血清ACE水平密切相关，DD型ACE基因可能是中国人冠心病发病的独立危险因子。
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| 关 键 词： | 血管紧张素转换酶 基因多态性 冠心病 |
| 收稿时间： | 1997-12-03 |
| 修稿时间： | 1998-05-12 |
Gene Polymorphism Analysis of ACE in Patients with Coronary Heart Disease and the Relation of the Genotypes to ACE Serum Level |
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| TAN Hong; ZHANG Guo-Yuano; YOU Nai-Zhen;HUANG Chao and LIU Jian-Ping. Gene Polymorphism Analysis of ACE in Patients with Coronary Heart Disease and the Relation of the Genotypes to ACE Serum Level[J]. Chinese Journal of Arteriosclerosis, 1998, 6(2): 134-136 |
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| Authors: | TAN Hong ZHANG Guo-Yuano YOU Nai-Zhen HUANG Chao LIU Jian-Ping |
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| Affiliation: | Department of Cardiology, General Hospital of Jinan Army,Jinan 250031,China |
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| Abstract: | Aim: To determine angiotensin converting enzyme (ACE) gene insertion/deletion (I/D) polymoprnhism in patients with coronary heart disease (CHD) and its relation with serum ACE levels.Methods: ACE genotypes of 6l patients with CHD and 63 healthy people were detected by PCR, and their serum ACE levels were concomitantly measured by microcolorimetric assay.Results: The frequency of DD genotype in patients with CHD was significantly higher than that in control group apd patients with DD genotype have higher serum ACE levels.Conclusion: ACE gene polymorphism is closely related to serum ACE level and DD genotype of ACE gene may be the independent risk factor of coronary heart disease in Chinese. |
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| Keywords: | Angiotensin-converting enzyme Gene polymrphism Coronary heart disease |
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