Analysis of differential therapeutic strategies for primary breast lymphoma: two case reports |
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Authors: | Roberto Stasi Maria Laura Evangelista Maurizio Brunetti Stefano Bussa Raffaele Maritati Luca Turrini Silvia Taccogna Anna Crescenzi Francesco Angelini |
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Institution: | (1) Department of Medical Sciences, Regina Apostolorum Hospital, Via S. Francesco, Albano Laziale, 5000041, Italy;(2) Division of Oncology and Hematology, Regina Apostolorum Hospital, Albano Laziale, Italy;(3) Department of Pathology, Regina Apostolorum Hospital, Albano Laziale, Italy |
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Abstract: | Primary breast lymphoma (PBL) is a rare form of extranodal non-Hodgkin’s lymphoma (NHL), whose own specific biological characteristics
still need to be fully defined. No significant prognostic factor has been found and the optimal therapeutic strategy is uncertain.
However, an intensified systemic therapy has been advocated to prevent relapse, even in patients who show a complete response
to local treatment. We report two cases of primary diffuse large B-cell breast lymphoma, review the literature about this
topic, and discuss treatment options. We conclude that differential therapeutic strategies based on the risk of relapse associated
with the International Prognostic Index (IPI) are a reasonable way to approach PBL, and can avoid undue toxicity deriving
from treatment. |
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Keywords: | Primary breast lymphoma International Prognostic Index Central nervous system Treatment Toxicity |
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