循环血中胰岛素样生长因子-I水平与非小细胞肺癌临床病理特征的相关性研究

目的 探讨循环血胰岛素样生长因子-I(IGF-I)在非小细胞肺癌(NSCLC)发展中的作用及其临床意义.方法 运用双抗夹心酶联免疫吸附反应定量检测80例原发性NSCLC患者和45例肺良性疾病患者循环血中IGF-I,分析循环血IGF-I水平与I临床病理特征的相关性.结果 NSCLC组循环血IGF-I水平显著高于肺良性疾病组;NSCLC患者循环血中IGF-I水平在肿瘤直径≥3cm组显著高于直径<3cm组,在伴局部淋巴结转移组显著高于无局部淋巴结转移组,在晚期(HI～Ⅳ)组显著高于早期(I～Ⅱ)组.结论 IGF-I可能以自分泌和/或旁分泌的方式促进NSCLC恶性进展.其自分泌和/或旁分泌水平与肿瘤大小、病理分期和淋巴结转移相关,体积大、分期晚、伴淋巴结转移的肺癌能分泌更多的IGF-I.检测循环血IGF-I水平对辅助判断NSCLC的分期可能有应用前景.

The Correlation between Circulating Insulin-like Growth Factor-I in Blood and Clinicopathological Parameters in Non-Small Cell Lung Cancer

Objective To explore the role of circulating insulin-like growth factor-I(IGF-I) in non-small cell lung cancer'(NSCLC)progression and its clinical significance.Methods Blood circulating IGF-I levels in 80 patients with NSCLC and 45 patients with benign pulmonary diseases were measured by using enzyme linked immunosorbent assay(ELISA) and the relationship between IGF-I level and clinicopathological parameters was analyzed.Results Blood circulating IGF-I level was significantly higher in patients with NSCLC than in those with benign pulmonary diseases.Blood circulating IGF-I was significantly higher in patients with NSCLC with advanced stages(stages Ⅲ and IV)or with the tumor diameter no less than 3 cm or with regional lymphoid node metastasis than in those with early stages(stages I or II) or with the tumor diameter less than 3 cm or without regional lymphoid node metastasis.Conclusion IGF-I may promote malignant progression of NSCLC in autocrine and/or paracrine manner.The autocrine and/or paracrine level of IGF-I is correlated with tumor diameter,tumor stage and regional lymphoid node metastasis.NSCLC with advanced stages,larger size and regional lymphoid node metastasis may secret more IGF-I.Measurement of circulating IGF-I may have clinical value to assess stages of NSCLC.