中老年男性2型糖尿病患者尿酸水平与肌少症的相关性研究

目的 探讨中老年男性2型糖尿病(type 2 diabetes mellitus,T2DM)患者尿酸与肌少症的相关性。方法 纳入首都医科大学宣武医院内分泌科275例≥55岁男性2型糖尿病患者,检测血尿酸(uric acid, UA)、25羟维生素D₃(25 hydroxyvitamin D₃, 25 OHD₃)、糖化血红蛋白(hemoglobin A1c, HbA1c)等浓度。测定四肢骨骼肌肌肉质量(appendicular skeletal muscle mass,ASM)、握力、步速等,并计算出四肢骨骼肌质量指数(appendicular skeletal muscle mass index, ASMI),分析UA与肌少症的相关性。结果 55岁以上男性T2DM患者肌少症患病率为32.73%,肌少症组患者UA明显低于非肌少症组[(307.5±76.57) mmol/L vs (342.02±89.02 )mmol/L,P=0.002]。Pearson相关分析显示,UA与ASMI呈正相关(r=0.201, P=0.006),UA与握力,步速无相关性(P＞0.05);多元Logistic 回归分析显示,UA是中老年男性T2DM患者肌少症的独立保护因素(OR=0.89,95%CI:0.79~0.97,P=0.043)。结论 尿酸对中老年男性T2DM患者的肌少症发挥一定的保护作用。

Relationship between uric acid and sarcopenia in middle-aged and aged men with type 2 diabetes mellitus

Objective To explore the relationship between uric acid (UA) and sarcopenia in middle-aged and aged men with type 2 diabetes (T2DM). Methods All 275 men with T2DM aged over 55 years were selected from the Department of Endocrinology of Xuanwu Hospital. The uric acid (UA), 25 hydroxyvitamin D₃ (25OHD₃), hemoglobin A1c (HbA1c) were measured. The appendicular skeletal muscle mass (ASM), grip strength and gait speed were assessed. In addition, appendicular skeletal muscle mass index (ASMI) was calculated. The association between uric acid and sarcopenia was assessed. Results The prevalence of sarcopenia in men aged over 55 years with T2DM was 32.73%, the level of uric acid in participants of the sarcopenia group was significantly lower than that in non-sarcopenia group [(307.5±76.57) mmol/L vs (342.02±89.02) mmol/L, P=0.002)]. Pearson correlation analysis showed that UA was significantly positively correlated with ASMI (r=0.201, P=0.006), and UA was not significantly correlated with grip strength and gait speed (P>0.05). Multivariate logistic regression analysis showed uric acid was an independent protective factor for sarcopenia in middle-aged and aged men with T2DM (OR=0.89,95%CI:0.79-0.97,P=0.043). Conclusion Uric acid plays a protective role in sarcopenia in middle-aged and aged men with T2DM.