1990―2019年中国肾癌死亡趋势及其年龄-时期-队列分析

  目的  分析全球健康数据交换(the Global Health Data Exchange, GHDx)数据库中中国肾癌的死亡趋势及其流行病学特征。   方法  收集GHDx数据库中1990―2019年间20~＜90岁中国人群肾癌死亡数据，运用Joinpoint回归模型分析肾癌死亡率的变化趋势，用年龄-时期-队列(age-period-cohort, APC)模型探讨影响肾癌死亡风险的年龄效应、时期效应与出生队列效应。   结果  1990―2019年全国、男性、女性肾癌标化死亡率均呈波动增长的趋势，平均年度变化百分比分别为2.04%、2.92%、0.70%；APC模型分析结果显示，无论男女，肾癌死亡风险均随着年龄的增长而增加，均随着时间的推移而增加，较晚出生的队列，其肾癌死亡风险均低于之前出生的队列。   结论  1990―2019年中国肾癌死亡率总体呈上升趋势，越早出生，年龄越大，生活在当代的人其肾癌死亡风险更高，肾癌造成的疾病负担仍是一个严重的公共卫生问题。

Analysis for mortality trend and age-period-cohort of kidney cancer in China from 1990 to 2019

  Objective  To analyze the mortality trends and epidemiological characteristics of kidney cancer in China from the Global Health Data Exchange (GHDx) database.   Methods  We collected the kidney cancer mortality data in China among adults aged 20- < 90 years in GHDx database from 1990 to 2019. Joinpoint regression model was used to estimate the mortality trends. Age-period-cohort model was used to explore the age effect, period effect and cohort effect.   Results  The standardized mortality of kidney cancer from 1990 to 2019 showed a fluctuating growth trend in the whole population and the subgroups of male and female, with the average annual change percentage of 2.04%, 2.92% and 0.70% respectively; For both male and female, the relative risk of kidney cancer mortality increased with advancing age and time period, but decreased from earlier birth cohorts to more recent birth cohorts.   Conclusions  The overall trends of the mortality of kidney cancer in China increased from 1990 to 2019. People who born earlier, being older, and living in modern times have a higher risk of kidney cancer mortality. The disease burden caused by kidney cancer is still a serious public problem.