女性绝经前后代谢综合征与胆结石发病情况关联

目的 分析金昌队列中女性人群胆结石发病率,探索绝经前后女性代谢综合征及其各组分与胆结石发病的关系.方法 采用前瞻性队列研究方法,以队列人群基线资料中未患胆结石的女性为研究对象,分析代谢综合征及其各组分对胆结石发病的影响.结果 本研究共纳入4196人,随访结束时有胆结石者195例,占比4.65％.在绝经后女性人群中,有代...

The association between metabolic syndrome and the risk of gallstones among premenopausal and postmenopausal women

  Objective  To analysis the incidence of gallstones among women in Jingchang cohort, and explore the relationship of metabolic syndrome and its components with the risk of gallstones among premenopausal and postmenopausal women.  Methods  A prospective cohort study was conducted to investigate the effects of metabolic syndrome and its components on the incidence of gallstones in women who did not have gallstones from baseline data.  Results  A total of 4 196 women were included in this study, and 195 (4.65%) had gallstones in follow-up. The incidence of gallstones in postmenopausal women with metabolic syndrome (10.91%) was higher than that in women without metabolic syndrome (5.68%, χ2 ＝19.982, P < 0.001). With the increase of the number of abnormal components, the incidence of gallstones gradually increased (χ2 _trend＝30.340, P < 0.001), and reached the maximum when multiple metabolic components were abnormal (12.24%). After adjusting for confounding factors, the risk of gallstones in postmenopausal women with multiple metabolic abnormalities was 6.839 times higher than that in the normal population (95% CI: 1.665-28.084, P＝0.008). The incidence of gallstones in people with abnormal waist circumference, TG, HDL-C, FPG were higher than those in normal subjects among postmenopausal women (all P < 0.05). After adjusting for confounding factors, the risk of gallstones in postmenopausal women with abnormal waist circumference (HR=1.805, 95% CI: 1.204-2.704, P＝0.004) and HDL-C (HR=1.451, 95%CI: 1.071-1.965, P＝0.016) were still higher than that in the normal population. In the grouping of metabolic syndrome, the abnormal number of metabolic syndrome and the normal or abnormal grouping of each component, the incidence of gallstones in postmenopausal women was higher than that in premenopausal women (all P < 0.05).  Conclusion  The incidence of gallstones in postmenopausal women is related to metabolic syndrome, and the incidence of gallstones in women is affected by menopausal status.