Increased perseverative errors following high-definition transcranial direct current stimulation over the ventrolateral cortex during probabilistic reversal learning |
| |
| Institution: | 1. Cognitive Neuroscience Unit, School of Psychology, Deakin University, Geelong, Victoria, Australia;2. Department of Psychiatry, University of Pittsburgh, PA, USA;3. Centre for Gambling Research at UBC, Department of Psychology, University of British Columbia, Vancouver, Canada;1. Psychology Clinical Neuroscience Center, Dept. Psychology, MSC03-2220, University of New Mexico, Albuquerque, NM, 87131, USA;2. Department of Psychology, University of New Mexico, Albuquerque, NM, 87131, USA;3. CCDC, Army Research Laboratory, Human Research and Engineering Directorate, Aberdeen Proving Ground, MD, 21005, USA;4. The Mind Research Network of the Lovelace Biomedical Research Institute, 1101 Yale Blvd. NE, Albuquerque, NM, 87106, USA;5. Center on Alcoholism, Substance Abuse, & Addictions, Albuquerque, NM, 87106, USA;6. U.S. Army Research Laboratory, Huntsville, AL, 35898, USA;1. Department of Psychology, Sociology and Politics, Sheffield Hallam University, Sheffield, UK;2. School of Biomedical Sciences, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong, SAR, China;3. Oxford Centre for Human Brain Activity, Wellcome Centre for Integrative Neuroimaging, Department of Psychiatry, University of Oxford, Oxford, UK;4. MRC Brain Network Dynamics Unit, University of Oxford, Oxford, UK;1. Department of Anatomy & Neurosciences, VU University Medical Center (VUmc), Amsterdam, The Netherlands;2. Department of Psychiatry VUmc, Amsterdam, The Netherlands;3. Neuroscience Campus Amsterdam, VU/VUmc, Amsterdam, The Netherlands;1. Centre for Clinical Research, The University of Queensland, Brisbane, Australia;2. Instiutute of Biomedical Engineering and Informatics, Technical University Ilmenau, Ilmenau, Germany;1. Department of Psychological and Brain Sciences, Texas A&M University, College Station, TX, USA;2. Texas A&M Institute for Neuroscience, Texas A&M University, College Station, TX, USA;1. Department of Psychology, The Brain Research Institute, University of California, Los Angeles, Los Angeles, CA, USA;2. Department of Neurosciences, University of New Mexico School of Medicine, Albuquerque, NM, USA;3. Laboratory of Behavioral and Genomic Neuroscience, National Institute on Alcohol Abuse and Alcoholism, Bethesda, MD, USA;4. Department of Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10014, USA |
| |
| Abstract: | BackgroundThe prefrontal cortex regulates behavioural adaptation in response to feedback. However, the causal role of different prefrontal regions remains unclear, based on indirect evidence derived from functional neuroimaging. Neuroimaging studies show dorsomedial prefrontal activation during feedback monitoring, whereas the ventrolateral prefrontal cortex engages during behavioural adaptation (shifting).ObjectiveWe used high-definition transcranial direct current stimulation (HD-tDCS) to elucidate the roles of the ventrolateral prefrontal cortex (vlPFC) and the dorsomedial prefrontal cortex (dmPFC) in behaviour change, using a probabilistic reversal learning task (PRLT).MethodFifty-two healthy adults were randomly assigned to receive cathodal HD-tDCS to inhibit the vlPFC or the dmPFC versus sham stimulation, prior to completing the PRLT. The outcome measures were the number of perseverative errors and the electroencephalography (EEG) signals of feedback-related negativity (FRN) in the PRLT. We hypothesised that inhibition of the vlPFC would be specifically associated with more perseverative errors and weaker FRNs.ResultsWe found that vlPFC inhibition was associated with higher perseverative errors compared to sham and dmPFC stimulation conditions. Although there were no statistically significant differences in FRN amplitudes, the effect sizes indicate an association between inhibition of the vlPFC and lower FRN amplitudes.ConclusionOur findings support a causal role of the vlPFC on feedback-based behavioural adaptation, which is critical for adaptive goal-driven behaviour. |
| |
| Keywords: | Ventrolateral prefrontal cortex Probabilistic reversal learning High-definition transcranial direct current stimulation Cathodal stimulation Perseverative errors Feedback-related negativity |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
