Effect of tube potential and luminal contrast attenuation on atherosclerotic plaque attenuation by coronary CT angiography: In vivo comparison with intravascular ultrasound |
| |
| Affiliation: | 1. Department of Imaging, Cedars-Sinai Medical Center, Los Angeles, CA, USA;2. Department of Cardiology, Kusatsu Heart Center, Kusatsu, Shiga, Japan;3. The Heart Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA;4. Biomedical Imaging Research Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA;1. Department of Radiology, St. Paul''s Hospital and University of British Columbia, Vancouver, BC, Canada;2. Department of Imaging, Cedars-Sinai Medical Center, Los Angeles, CA, USA;3. Centre for Heart Lung Innovation, St. Paul''s Hospital and University of British Columbia, Vancouver, BC, Canada;4. Icahn School of Medicine at Mt. Sinai Hospital, New York, NY, USA;5. Department of Radiology and Nuclear Medicine, German Heart Center Munich, Munich, Germany;6. Seoul National University Hospital, Seoul, South Korea;7. Centro Cardiologico Monzino, IRCCS, Milan, Italy;8. Department of Medicine, Harbor UCLA Medical Center, Los Angeles, CA, USA;9. Department of Radiology, Casa de Saude São Jose, Rio de Janeiro, Brazil;10. Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, South Korea;11. Seoul National University Bundang Hospital, Bundang, South Korea;12. SDN IRCCS, Naples, Italy;13. Department of Radiology, Area Vasta 1, ASUR Marche, Urbino, Italy;14. Hospital da Luz, Lisbon, Portugal;15. National Health Insurance Service Ilsan Hospital, South Korea;p. Busan University Hospital, Busan, South Korea;q. Department of Pathology, CVPath Institute, Gaithersburg, MD, USA;r. Division of Cardiology, Emory University School of Medicine, Atlanta, GA, USA;s. Cardiovascular Division, Brigham and Women''s Hospital, Harvard Medical School, Boston, MA, USA;t. Department of Imaging, Cedars-Sinai Medical Center, Cedars-Sinai Heart Institute, Los Angeles, CA, USA;u. Zena and Michael A. Wiener Cardiovascular Institute, Marie-Josee and Henry R. Kravis Center for Cardiovascular Health, New York, NY, USA;v. Weill Cornell Medical College, New York, NY, USA;w. Department of Cardiology, Heart Lung Center, Leiden University Medical Center, Leiden, the Netherlands;x. Division of Cardiology, Severance Cardiovascular Hospital, Integrative Cardiovascular Imaging Center, Yonsei University College of Medicine, Seoul, South Korea |
| |
| Abstract: | BackgroundIt has been shown that CT attenuation of noncalcified plaques depends on luminal contrast attenuation (LCA). Although tube potential (kilovolt [kV]) has been shown to exert influence on plaque attenuation through LCA as well as its direct effects, in-vivo studies have not investigated plaque attenuation at lower tube potentials less than 120 kV. We sought to evaluate the effect of kV and LCA on thresholds for lipid-rich and fibrous plaques as defined by intravascular ultrasound (IVUS).MethodsCT attenuation of IVUS-defined plaque components (lipid-rich, fibrous, and calcified plaques) were quantified in 52 consecutive patients with unstable angina, who had coronary CT angiography performed at 100 kV (n = 25) or 120 kV (n = 27) using kV-adjusted contrast protocol prior to IVUS. CT attenuation of plaque components was compared between the two groups.ResultsLCA was similar in the 100-kV and 120-kV groups (417.6 ± 83.7 Hounsfield Units [HU] vs 421.3 ± 54.9 HU, p = 0.77). LCA correlated with CT attenuation of lipid-rich (r = 0.49, p = 0.001) and fibrous plaques (r = 0.32, p < 0.05), but not with that of calcified plaques (r = 0.04, p = 0.81). When plaque attenuation was normalized to LCA, lipid-rich (0.087 ± 0.036, range −0.012–0.147) and fibrous plaque attenuation (0.234 ± 0.056, range 0.153–0.394) were distinct (p < 0.001) with no overlap for both kV groups. CT attenuation was not significantly different between 100-kV and 120-kV groups for lipid-rich (34.0 ± 21.5 vs 39.3 ± 12.9, p = 0.33) or fibrous plaques (95.4 ± 19.1 vs 97.6 ± 22.0, p = 0.75).ConclusionPlaque attenuation thresholds for non-calcified plaque components should be adjusted based on LCA. Further adjustment may not be required for different tube potentials. |
| |
| Keywords: | Coronary computed tomography angiography Plaque characterization Tube potential Intravascular ultrasound |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
