3D-ASL与DSC-PWI在脑肿瘤灌注成像中的一致性分析

目的 对比分析三维动脉自旋标记（3D-ASL）和动态磁敏感对比增强扫描灌注成像（DSC-PWI）在脑肿瘤灌注中脑血流量测量的一致性。方法 19例脑肿瘤患者，其中胶质瘤9例，脑膜瘤5例，血管母细胞瘤2例、转移瘤2例，海绵状血管瘤1例。所有病例均经手术病理证实。术前均行常规磁共振平扫、增强扫描及 3D ASL和 DSC-PWI灌注成像，比较19例脑肿瘤患者57个感兴趣区脑血流量(CBF)与相对脑血流量(rCBF)的差异，评价两者之间的一致性。结果 3D ASL所测CBF与DSC 所测rCBF值两者有显著相关性（P=0.005），一致性较好。结论 3D-ASL与 DSC-PWI在评估脑肿瘤脑血流量方面具有一致性，3D-ASL可准确评估脑肿瘤灌注情况。

Consistency analysis between 3D arterial spin labeling and dynamic susceptibility contrast perfusion magnetic resonance imaging in perfusion imaging of brain tumor

Objective To analyze the consistency between cerebral blood flow (CBF) of 3D arterial spin labeling (3D ASL) and dynamic susceptibility contrast perfusion magnetic resonance imaging (DSC-PWI) in the measurement of brain tumors. Methods Nineteen patients with pathologically confirmed brain tumors were enrolled in this study. The brain tumors included glioma (n=9), meningioma (n=5), hemangioblastoma (n=2), cerebral metastasis (n=2) and cavernous hemangioma (n=1). Both ASL and DSC MRI were performed in all the 19 patients (57 regions of interest), and CBF was quantitatively determined. Results A significant consistency was found between CBF measured by 3D ASL and the relative CBF (rCBF) determined by DSC (P=0.005). Conclusion 3D ASL and DSC PWI are consistent in evaluating blood flow in brain tumors and can accurately evaluate brain tumors perfusion.