神经外科重症监护病房导管相关性感染病原菌分布与耐药性分析

目的探讨神经外科重症监护病房导管相关性感染病原菌分布及其对常用抗菌药物的耐药情况。方法对2008年1月～2010年12月送检的169例导管标本进行分离培养,并对分离出的病原菌进行抗菌药物敏感性检测。结果共检出导管相关性感染病原菌62株,其中革兰阳性球菌38株,革兰阴性杆菌24株,以表皮葡萄球菌(15株,24.19%)、鲍曼不动杆菌(9株,14.52%)、金黄色葡萄球菌(8株,12.90%)、溶血葡萄球菌(6株,9.68%)和肺炎克雷伯菌(6株,9.68%)为主要病原菌;药敏结果示革兰阳性菌对万古霉素较为敏感,而革兰阴性菌对亚胺培南敏感性较高。结论神经外科重症监护病房导管相关性感染以革兰阳性球菌为主,并呈现多重耐药性。

Distribution and antimicrobial resistance of venous catheter-related infections in a neurosurgical intensive care unit

Objective To investigate the distribution of pathogens responsible for venous catheter-related infections in a neurosurgical intensive care unit(NICU) and their drug resistance.Methods The pathogens from 169 catheter specimens collected from January 2008 to December 2010 were isolated and cultured and the drug sensitivity testing of the isolated pathogens was performed.Results In total,62 strains of bacteria responsible for venous catheter-related infection were identified;of these,38 strains were Gram-positive cocci while 24 were Gram-negative bacilli.Staphylococcus epidermidis(24.19%),Acinetobacter baumannii(14.52%),Staphylococcus aureus(12.90%),Staphylococcus hemolyticus(9.68%),and Klebsiella pneumonia(9.68%) were the pathogens isolated most often.The results of drug sensitivity testing showed that Gram-positive bacterial isolates were sensitive to vancomycin while Gram-negative bacteria were sensitive to imipenem.Conclusion Gram-positive cocci were the pathogens predominantly responsible for venous catheter-related infections in a NICU,and these pathogens have multidrug resistance.