Genes for Neuronal Properties Expressed in Neuroblastoma × L Cell Hybrids |
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| Authors: | John Minna Phillip Nelson John Peacock Devera Glazer Marshall Nirenberg |
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| Affiliation: | Laboratory of Biochemical Genetics, National Heart and Lung Institute, National Institutes of Health, Bethesda, Maryland 20014;Behavioral Biology Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20014 |
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| Abstract: | Neuroblastoma cells with electrically excitable membranes were fused with electrically passive L cells having a hitherto undescribed electrical marker. Hybrid cells, examined 10-40 generations after fusion, were found to be electrically excitable. The results show that at least a part of the genetic information for neuron differentiation can be functionally expressed in N x L hybrid cells. Evidence for the regulation of action potential components was also found. |
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