埃索美拉唑对十二指肠球溃疡合并幽门螺杆菌感染的治疗

目的:观察埃索美拉唑加利复星、克拉霉素治疗十二指肠溃疡合并幽门螺杆菌(H Pylori) 感染的临床疗效．方法:将64例幽门螺杆菌阳性的十二指肠球溃疡患者随机分为治疗组(n=32)和对照组(n= 32)．治疗组口服埃索美拉唑、利复星、克拉霉素．对照组口服法莫替丁、利复星、克拉霉素．各组疗程结束后复查胃镜,观察溃疡愈合率、H pylori清除率和临床症状的改善情况．结果:治疗组和对照组镜下溃疡愈合率分别为32例(100％)和26例(81．3％)(P<0．01);H pylori根除率分别为90．6％和71．9％(P<0．01); 治疗组显效32例,总有效率100％;对照组显效率20例(62．5％),有效8例(25％),总有效率 87．5％．治疗组显效率和总有效率显著高于对照组(P<0．01)．两组均无明显不良反应．结论:埃索美拉唑缓解临床症状快,有效促进溃疡愈合,与抗生素联合应用提高H pylroi清除率．

Efficacy of Esomeprazole in treatment of duodenal ulcer complicated with Helicobacter Pylori Infection

AIM: To observe the effects of Esomeprazole plus Lifuxing plus Clarithromycin in the treatment of duodenal ulcer complicated with Helico bacter Pylori infection. METHODS: Sixty-four patients with duodenal ulcer, who were positive for Helicobacter Pylori (H Pylori), were randomly assigned to group A (n = 32) and B (n = 32). The patients in group A were treated with Esomeprazole (40 mg) plus Lifuxing (0.2 g) plus Clarithromycin (0.5 g), while those in group B were treated with Famotidine (20 mg) plus Lifuxing (0.2 g) plus Clarithromycin (0.5 g). At the end of treatment, the cure rate of duodenal ulcer and the rate of H Pylori eradication as well as the improvement of clinical symptoms were analyzed. RESULTS: The cure rates of the patients were 100% and 81.3% in group A and B, respectively, and there was significant difference between them (P < 0.01). The rate oiH Pylori eradication were 90.6% and 71.9% in group A and B, respectively, and there also existed significant difference between them (P < 0.01). All the patients in group A had complete improvement of the clinical symptoms (markedly and total effective rate: 100%), which showed a marked difference in comparison with group B (markedly effective rate: 62.5%; total effective rate: 87.5%) (P < 0.01), and no significant adverse reactions were observed in both groups. CONCLUSION: Esomeprazole can effectively cure the ulcer of the duodenal bulb, and it can enhance the rate of H pylori eradication when combined with antibiotics.