应用肺表面活性物质对早产儿视网膜病发生的影响

[摘要] 目的 探讨早产儿应用肺表面活性物质（PS）对早产儿视网膜病（ROP）发生的影响。方法 发生肺透明膜病（RDS）并能随访的早产儿随机分成两组，对照组76例仅吸氧或辅助通气及其他常规治疗，治疗组80例早产儿此基础上予PS治疗，监测两组早产儿呼吸机、用氧时间、住院时间和ROP的发病率。结果 治疗组早产儿的平均上机时间、用氧时间、住院时间分别是2.5±0.3、6.1±0.4、23.4±0.9，均明显少于对照组，治疗组发生ROP5例，占6.3 %，对照组发生ROP13例，占17.1%，治疗组ROP发生率低于对照组，差异有显著性。结论 应用PS可以减少早产儿ROP的发生。

Influence of pulmonary surfactant on retinopathy in preterm infant

Abstract Objective To investigate the effects of pulmonary surfactant replacement Therapy on premature infants for preventing retinopathy of prematurity (ROP). Methods 156 premature infants with respiratory distress syndrome (RDS) were divided into 2 groups,80 cases were treated with PS, 76 cases were treated with usually way, ROP occurrence rate and turnover were observed. Results The premature infants treated with PS need less time of mechanical ventilation and hospitalization, and had a lower ROP occurrence rate as 17.1%, It was significantly different between the two groups(P<0.05). Conclusion Pulmonary surfactant has the preventative effect to ROP.