| rhKD／APPvar对实验性慢性肝损伤肝组织纤维化影响的研究 |
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| 引用本文： | 孟威宏,王虹蛟,王强,颜炜群,任立群.rhKD／APPvar对实验性慢性肝损伤肝组织纤维化影响的研究[J].中国实验诊断学,2013,17(2):255-258. |
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| 作者姓名： | 孟威宏 王虹蛟 王强 颜炜群 任立群 |
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| 作者单位： | 沈阳军区总医院;长春解放军第461医院;吉林大学再生医学科学研究所 |
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| 基金项目： | 国家自然基金课题(课题编号30300153) |
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| 摘 要： | 目的探讨重组人淀粉样蛋白前体Kunitz型蛋白酶抑制剂结构域变异体（reorganization human Kunitzprotease inhibitor domain of amyloid protein precursor variant,rhKD/APPvar）对实验性慢性肝损伤大鼠肝组织纤维化的影响。方法利用实验鼠的四氯化碳（CCl4）慢性肝损伤模型,采用胶原纤维染色检测方法,观察rhKD/APPvar对慢性肝损伤大鼠肝组织纤维化改变的影响。结果随着rhKD/APPvar剂量的增加,胶原纤维增生减轻。尤其以rhKD/APPvar大剂量组效果最为明显。结论 rhKD/APPvar能够显著抑制大鼠肝脏纤维化。
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| 关 键 词： | rhKD APPvar 四氯化碳 慢性肝损伤 大鼠 胶原纤维染色 |
Influence of rhKD/APPvar on the fibrosis of hepatic tissue in Wistar rats with chronic liver injury |
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| Institution: | MENG Wei-hong,WANG Hong-jiao,WANG Qiang,et al.(1.The General Hospital of Shenyang Military District;Shenyang 110015,China ;2.The 461 Hospital of PLA;3.The Institute of Frontier Medical Science,Jinlin University) |
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| Abstract: | Objective To investigate the influence of reorganization human Kunitz protease inhibitor domain of amy- loid protein precursor variant （rhKD/APPvar） on the fibrosis of hepatic tissue in Wistar rats with chronic liver injury. Methods The chronic liver injury model of rats was induced by carbon tetrachloride （CC14）. The method of collage- nous fibers dyeing was employed to observe the effect of rhKD/APPvar on the rats＇ hepatic tissue fibrosis. Results With the increase of the dose of rhKD/APPvar,the collagenous fibers hyperplasia decreased. The large dose of rhKD/ APPvar group was most effective in reducing fibrosis. Conclusion The rhKD/APPvar could inhibit rats＇ hepatic tissue fibrosis significantly. |
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| Keywords: | rhKD/APPvar Carbon tetrachloride Chronic hepatic injury Wistar Rats Collagenous fibers dyeing |
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