两种艾滋病病毒新近感染检测方法在比较不同感染途径患者死亡情况中的应用

目的应用两种艾滋病病毒(HIV)新近感染检测方法区分出HIV新近感染人群,探讨不同感染途径新近感染人群的死亡速度。方法采用ML-PA、BED-CEIA两种HIV-1新近感染检测方法对2006-2011年新报告的HIV/AIDS进行检测,对不同感染途径HIV/AIDS新近感染人群中位生存时间进行分析。结果对2006-2011年2 018例新报告的HIV/AIDS采用ML-PA进行HIV-1新近感染检测,得出新近感染64例(3.17%,95%CI:2.41%～5.58%),其中累计死亡3例(4.69%,95%CI:4.17%～5.29%),性、吸毒感染死亡分别2例、1例;对2009-2011年388例新报告的HIV/AIDS采用BED-CEIA进行HIV-1新近感染检测,得出新近感染35例(9.02%,95%CI:6.17%～15.19%),其中累计死亡2例(5.71%,95%CI:4.94%～6.48%),2例均为异性途径感染死亡。结论两种实验室HIV新近感染检测方法区分出的不同感染途径HIV/AIDS新近感染人群中位生存时间均大于2年。

Comparison of two methods for the detection of HIV-1 infection, trace of infection routes and death of newly infected patients in Yuxi,Yunnan

Objective To compare two methods for the detection of HIV-1 infection to determine the newly infected and to trace the infection routes and death of those newly infected patients.Methods The ML-PA and BED-CEIA HIV-1 for newly infection testing were used to detect HIV-1 among newly reported HIV/AIDS cases in Yuxi from 2006 to 2011.Results Out of 2 018 newly reported HIV/AIDS cases,64 were found positive by ML-PA testing with the positive rate of 3.17%（95% CI： 2.41-5.58%）,and 3 patients died which accounted for 4.69%（95% CI： 4.17-5.29%）.Among them,2 died from infection with sexual transmission and the other died from infection by drug abuse.However,there were 35 positive out of 388 newly reported patients with the positive rate of 9.02%（95% CI： 6.17-15.19%）,and 2 died which accounted for 4.69%（95% CI：4.17-5.29%）.Both died from infection with heterosexual transmission.Conclusions The median survival time of newly infected HIV-1 patients both by sexual transmission and drug use is longer than 2 years concluded by the testing of ML-PA and BED-CEIA.