| P53和C－fos蛋白在肾细胞癌中的表达 |
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| 引用本文： | 牛天力,俞天麟,张绍增,邢传平,范顺才,刘华福. P53和C－fos蛋白在肾细胞癌中的表达[J]. 中华泌尿外科杂志, 1996, 0(1) |
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| 作者姓名： | 牛天力 俞天麟 张绍增 邢传平 范顺才 刘华福 |
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| 作者单位： | 兰州军区总医院泌尿外科 |
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| 摘 要： | 用免疫组织化学方法对６２例石蜡包埋的肾细胞癌（ＲＣＣ）标本中的Ｐ５３和Ｃ－ｆｏｓ蛋白进行检测。结果：Ｐ５３和Ｃ－ｆｏｓ蛋白表达均位于肿瘤细胞的细胞核内，其中Ｐ５３蛋白阳性３８例占６１．３％，ｃ－ｆｏｓ蛋白阳性３３例占５３．２％。Ｐ５３蛋白和肾细胞癌的病理学分类无关，但Ｐ５３和Ｃ－ｆｏｓ蛋白随透明细胞癌的分期升高而高表达，并和预后有密切关系。
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| 关 键 词： | 肾肿瘤，蛋白质，基因，免疫组化 |
Expression of P53 and C-fos protein in renal cell carcinoma |
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| Niu Tianli,Yu Tianlin,Zhang Shaozeng,etal.. Expression of P53 and C-fos protein in renal cell carcinoma[J]. Chinese Journal of Urology, 1996, 0(1) |
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| Authors: | Niu Tianli Yu Tianlin Zhang Shaozeng etal. |
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| Abstract: | The expression of P53 and C-fos protein was detected by immunohistochemical assay in paraffin embeded specimens of 62 cases of renal cell carcinoma,The results revealed that the nucleus of the tumor cells was the site of P53 and C-fos protein.P53 protein was positive in 38 cases(6l.3%)and C-fos protein in 33(53.2%).Both the proteins were related to the staging and grading of the tumor,the worse the staging and grading the higher the presence of P53 and C-fos protein,and were also related to the prognosis of the the patients. |
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| Keywords: | Kidney neoplasms Proteins Genes Immunohistochemistry |
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