Kadsuphilols A-H, oxygenated lignans from Kadsura philippinensis |
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Authors: | Shen Ya-Ching Cheng Yuan-Bin Lan Ting-Wei Liaw Chia-Ching Liou Shorong-Shii Kuo Yao-Haur Khalil Ashraf Taha |
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Institution: | School of Pharmacy, College of Medicine, National Taiwan University, Taipei, Taiwan 100, Republic of China. ycshen@ntu.edu.tw |
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Abstract: | Eight new oxygenated lignans, kadsuphilols A-H (1-8), were isolated from the leaves and stems of Kadsura philippinensis. Four of the isolated lignans (1-4) possess the normal C18-dibenzocyclooctadiene skeleton, while the other four lignans (5-8) are C19-homolignans possessing a substituted cyclohexadienone ring with a spiro-benzofuranoid moiety. The structures of the isolated metabolites were elucidated through spectroscopic analyses, including 2D NMR experiments. Compounds 1 and 4 are the first report of an R-biphenyl configuration with a beta-oxygenated substituent at the C-9 position. The in vitro radical-scavenging activities of these compounds using DPPH were tested and evaluated. Compound 3 exhibited more potent activity than vitamins C and E. |
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