| 盐酸西布曲明的合成 |
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| 引用本文： | 徐云根,罗穗,华维一. 盐酸西布曲明的合成[J]. 中国现代应用药学, 2000, 17(5): 380-381 |
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| 作者姓名： | 徐云根 罗穗 华维一 |
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| 作者单位： | 中国药科大学药物化学研究室,南京,210009 |
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| 摘 要： | 目的：改进肥胖症治疗药盐酸西布曲明（ｓｉｂｕｔｒａｍｉｎｅ ｈｙｄｒｏｃｈｌｏｒｉｄｅ）的合成方法。方法：以４－氨苄腈为起始原料，经环烃化、Ｇｒｉｇｎａｒｄ反应、还原、Ｅｓｃｈｗｅｉｌｅｒ－ｃｌａｒｋｅ甲基化和成盐等反应合成了盐酸西布曲明。结果：合成产物经熔点、元素分析、红外光谱和核磁共振谱等确证，总收率３６．３％。结论：此合成工艺简便，易于工业化生产。
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| 关 键 词： | 减肥药 盐酸西布曲明 合成 |
Synthesis of sibutramine hydrochloride |
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| Xu Yungen(Xu YG,Luo Sui(Luo S,Hua Weiyi(Hua WY. Synthesis of sibutramine hydrochloride[J]. The Chinese Journal of Modern Applied Pharmacy, 2000, 17(5): 380-381 |
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| Authors: | Xu Yungen(Xu YG Luo Sui(Luo S Hua Weiyi(Hua WY |
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| Abstract: | OBJECTIVE:To modify the synthetic method of sibutramine hydrochloride.METHOD:Sibutramine hydrochloride was synthesized from 4 chlorophenylacetonitrile by reactions of cycloalkylation,Grignard reaction,reduction,Eschweiler Clarke methylation and salifying.RESULTS:The chemical structure of the product was identified by melting point,element analysis,IR and 1HNMR.The total yield was 36.3%.CONCLUSION:This synthetic technique is simple and easy to produce on industrial scale. |
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| Keywords: | sibutramine anti-obesity drug synthesis |
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