L-精氨酸预防慢性低氧大鼠右心肥厚的实验研究

目的探讨L- 精氨酸(L Arg)对低氧状态下大鼠肺动脉高压及右心肥厚的预防作用。方法建立常压低氧性肺动脉高压大鼠模型,用L -Arg和L -精氨酸甲酯(L- NAME)进行预防处理,检测动物平均肺动脉压(mPAP)和右心室/左心室+室间隔重量之比RV/(LV+S) ],并测定血浆中的NO含量。结果L- Arg预处理组,平均肺动脉压及RV/(LV+S)明显低于单纯低氧组(P<0. 05),血浆NO含量则明显高于单纯缺氧组(P<0. 01),L- NAME组与单纯低氧组相比,上述各指标则无显著性差异(P>0. 05)。结论L -Arg对低氧性肺动脉高压及右心肥厚有明显的预防作用。

The Protective Study of L-arginine on Chronically Hypoxic Right Ventricular Hypertrophy in Rats

Objective To investigate the protective effect and mechanism of L-arginine(L-Arg) on chronically hypoxia-induced pulmonary hypertension and right ventricular hypertrophy in rats. Methods The models of isobaric hypoxic pulmonary hypertension were established, and pretreatment with L-Arg and L-NAME(NG-Aitro-L-arginine methyl ester). The mean pulmonary artery pressure(mPAP)and the rate of right ventricle and left ventricle plus septum and the level of NO in plasma were determined.Results The mPAP and RV/(LV+S) in L-Arg group were significantly lower and the level of NO was significantly higher than in the simple hypoxic group(P<0.05 and P<0.01).In comparison with simple hypoxic group, the above indexes in L-NAME group were not significant difference(P>0.05).Conclusion L-Arg might be effective protector for chronically hypoxic pulmonary hypertension and right ventricular hypertrophy in rats.