胃癌手术后早期肠内营养对T淋巴细胞亚群的影响

目的：探讨早期肠内营养对胃癌病人手术后Ｔ淋巴细胞免疫功能的影响。方法：３０例胃癌根治术病人随机分成３组，即对照组、肠外营养组（ＰＮ组）、肠内营养组（ＥＮ组），分别给予普通静脉输液、肠外营养及肠内营养８ｄ。术前及术后第１、３、６、９天以碱性磷酸酶－抗碱性磷酸酶（ＡＰＡＡＰ）法测定Ｔ淋巴细胞亚群（ＣＤ３、ＣＤ４、ＣＤ８）的变化。结果：对照组和ＰＮ组术后ＣＤ３、ＣＤ４阳性细胞数及ＣＤ４／ＣＤ８比值明显降低，ＣＤ８阳性细胞数明显升高。ＥＮ组术后第１天ＣＤ３、ＣＤ４阳性细胞数及ＣＤ４／降低，但自术后第３天起即开始上升，并逐渐恢复至术前水平；术后第３、６、９天ＣＤ３、ＣＤ４阳性细胞数及ＣＤ４／ＣＤ８比值明显高于对照组和ＰＮ组（Ｐ〈０．０５），而ＣＤ８阳性细胞数明显低于对照组和ＰＮ组（Ｐ〈０．０５），术后第９天时ＣＤ４／ＣＤ

THE EFFECTS OF EARLY ENTERAL NUTRITION ON T-LYMPHOCYTE SUBSETS IN PATIENTS WITH GASTRIC CARCINOMA AFTER OPERATION

Objective:To explore the effect of early enteral nutrition on T-lymphocyte subsets in patients with gastric carcinoma after operation.[WT5HZ]Methods:Thirty patients with gastric carcinoma were divided into three groups after radical resection,contral group,PN group,and EN group.The changes of T-lymphocyte subsets were determined by APAAP method on the 0,1,3,6,9 day postoperatively.[WT5HZ]Results:The CD 3 and CD 4 positive cell counts and CD 4/CD 8 rate decreased and CD 8 cell count increased in contral group and PN group significantly after operation.In EN group,the CD 3 and CD 4 positive cell counts and CD 4/CD 8 rate decreased on the lst day after operation,but then recovered gradually from the 3th day after operation.The CD 3 and CD 4 positive cell count and CD 4/CD 8 rate in TEN group were higher than those in contral group and PN group on the 3th,6th,9th days after operation( P <0 05) [WT5HZ]Conclusions:Early enteral nutrition can enhance T-lymphocyte immune function and improve lymphocytic immunosuppression after operation in patients with gastric carcinoma. [WT5HZ]