2型糖尿病患者红细胞免疫功能与血糖、胰岛素水平的相关性探讨

目的 :探讨了 2型糖尿病患者红细胞免疫功能的变化及其与血糖和胰岛素的相关性。方法 :应用免疫法测定 5 2例 2型糖尿病患者红细胞免疫功能 ,酶法测定血糖 ,放免法测定胰岛素含量并与 35名正常人作对照。结果 :2型糖尿病患者RBC -C3bRR水平明显降低 (p <0 0 1)与血糖和胰岛素水平呈负相关 (r=-0 32 5 1、- 0 3312 ,p<0 0 5 ) ,RBC -ICRRR水平明显高于正常人 (p <0 0 1) ,与血糖和胰岛素水平呈正相关 (r=0 35 12、0 346 4 ,p <0 0 5 )。结论 :2型糖尿病患者存在有红细胞免疫调节的紊乱 ,其免疫功能的低下与血糖和胰岛素升高有相关性。

Study on the Changes in Erythrocyte Inmune Systerm Function and the Correlation to the Levels of Blood Glucose and Insulin in Patients with Type 2 Diabetes Mellitus

Objective To investigate the changes in Erythrocyte immune system function and the correlation to the levels of blood glucose and insulin in patients with type 2 diabetes mellitus. Methods Erythrocyte immune system function was determined by inmune method, sugar by enzyme method and insulin by RIA in 52 patients with type 2 diabetes mellitus as well as 35 ccontrols. Results The RBC-C3bRR levels in patients were significantly lower than those in controls ( p <0 01) and exhibited a negative linear correlation to blood glucose and insulin levels ( r=-0 3251?-0 3312,p <0 05). RBC-ICRR levels in patients were remarkably higher than those in controls ( p <0 01) and exhibited a positive linear correlation to blood glcose and insulin levels ( r=0 3512?0 3464,p <0 05). Conclusion There are disturbances of erythrocyte immune system function are in DM-2 patients, the severity of which is related to the increase of blood sugar and insulin levels.