多发性硬化动物模型系列MRI与病理对照研究

目的研究多发性硬化(MS)动物模型—恒河猴实验性变态反应性脑脊髓炎(EAE)在MRI上显示病变的组织病理学基础。方法建立EAE的动物模型,系列MRI并与病理及临床进行对照研究。结果实验组9只动物全部发病,常规MRI在显示其病理结构上无特异性,强化扫描有助于区别活动性斑块和非活动性斑块,并可做为脱髓鞘病变的定位参考。磁化转移成像(MTI)提高了小病变的检出率。对应病变区病理可见袖状结构、轴突损伤、脱髓鞘改变。结论MR系列成像对于准确评价恒河猴EAECNS病变、推测其组织病理学改变有潜在的应用价值。

Investigations of serial MR imaging and histopathology for experimental allergic encephalomyelitis in the rhesus monkeys

Objective To study the histopathological basis of MRI-detectable lesion in the EAE model of rhesus monkey.Methods Firstly,the model of rhesus EAE can b e established.Then serial MR imagin g was performed.The MRI,clinical an d pathology were compared and correlated for evaluation in the CNS over disease process.Result Nine animals all attacked .The conventional MRI absents speciality in revealing pathologic structure.Gd-DTPA enhancement helped to distinguish active plaques fr om inactive plaques.It can be as located reference sign where should be occur demyelination.MT imaging i mprove the rate of finding out little lesions.Histopathologic exam-ination in relative area revealed perivascular flammatory cuffing and d emyelination and axons injure .Conclusions serial MR studies are an important method to clinical and his topathologic analysis for the evalu ation of CNS lesion in the EAE.