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文拉法辛与氟西汀治疗抑郁症的对照研究
引用本文:宋志文,李耀东,蔡理荣. 文拉法辛与氟西汀治疗抑郁症的对照研究[J]. 中国民康医学, 2006, 18(17): 739-740
作者姓名:宋志文  李耀东  蔡理荣
作者单位:广东省佛山市顺德区伍仲珮纪念医院,广东,佛山,528333
摘    要:目的:比较文拉法辛与氟西汀治疗抑郁症的疗效和安全性。方法:将80例抑郁症患者随机分为两组,分别给予文拉法辛与氟西汀治疗,疗程6周,用汉密顿抑郁量表(17项,HAMD)评定临床疗效,用副反应量表(TESS)评定不良反应。结果:第1、2周末两组间HAMD评分差异有显著性;两组总有效率及不良反应差异无显著件。结论:文拉法辛抗抑郁作用起效较快,疗效及不良反应与氟西汀相当。

关 键 词:文拉法辛 氟西汀 抑郁症
收稿时间:2006-01-03

Comparative study of venlafaxine and fluoxetine in the treatment of depression
SONG Zhi-wen,LI Yao-dong,CAI Li-rong. Comparative study of venlafaxine and fluoxetine in the treatment of depression[J]. medical journal of chinese peoples health, 2006, 18(17): 739-740
Authors:SONG Zhi-wen  LI Yao-dong  CAI Li-rong
Affiliation:Wuzhong -pei Memorial Hospital of Shunde, Foshan 528333, China
Abstract:Objective:To compare the efficacy and side effects of venlafaxine and fluoxetine in the treatment of depression. Methods:80 patients with depression were randomly assigned to venlafaxine group and fluoxetine group for 6 weeks.The efficacy was evaluated with Hamilton depression scale(HAMD),and the side effects were evaluated with treatment emergent symptoms scale(TESS).Results: The total score of HAMD in venlafaxine group was significantly lower than that in fluoxetine group after one-week and two-week treatment.No significant differences were found in clinical efficacy and side effects between two groups.Conclusions: Both venlafaxine and fluoxetine are effective antidepressants with fewer side effect.However,venlafaxine took effect more quickly.
Keywords:Venlafaxine    Fluoxetine    Depression
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