DICE方案治疗难治性或复发性NHL

目的观察DICE方案治疗难治或复发性非霍奇金淋巴瘤（NHL）的疗效及不良反应。方法采用地塞米松、异环磷酰胺、美安及顺铂联合治疗21例NHL观察其治疗及不良反应。结果21例中，完全缓解（CR）7例，部分缓解（PR）7例，有效率（RR）66．7％。复发组13例中CR6例、PR5例、RR84.6％，明显高于对照组8例中的1例、2例及37．5％，均P〈0.01。DICE方案的主要不良反应表现为骨髓抑制，恶心呕吐和脱发，患者均可耐受。结论DICE方案治疗复发性NHL比难治性疗效好，提示复发和难治性NHL可能有不同的生物学行为，两者应选择不同的治疗方案。

Effect of DICE Regimen on Patients with Refractory of Relapsed Non-Hodgkin's Lymphoma

Objective To explore efficiency and toxicity of DICE regimen on patients with refractory or relapsed non-Hodgkin's lymphoma (NHL). Methods 21 patients with refractory or relapsed non-Hodgkin's lymphoma were treated by DICE regimen. Results Complete response (CR) was seen in 7 patients (33.3%), and partial response (PR) was noted in 7 patients (33.3%), the response rate (RR) was 66.7%. In DICE group, 13 patients with relapsed NHL, the response rate (11/13) and complete response rate (6/13) were significant higher than in control group (3/8, 1/8) (P<0.01). Toxicity was myelosuppression, nausea/vomit and alopecia. All the patients can tolerance the side effects. Conclusions The effect off DICE regimen on relapsed NHL is better than on refractory NHL, this suggested that there may be different biology character between them, and different strategies should be provided for them.