类风湿关节炎的诊断及治疗进展

类风湿关节炎（RA）是一种常见的全身自身免疫性疾病，目前尚无特异性诊断及治疗方法，尤其对于不典型和特殊类型RA易误诊误治。近年来，抗角蛋白抗体（AKA）、抗核周因子抗体（APF）、抗环瓜氨酸肽抗体（抗CCP抗体）、抗RA33和抗Sa等新型自身抗体的发现提高了RA诊断的敏感性和特异性；核磁共振、CT及超声检查等影像学检查提高了RA关节损害的检出率，这些新的血清学检测指标及影像学检查的应用有助于RA的早期诊断。抗风湿药（DMARDs）和生物制剂问世，RA的治疗手段不断丰富。绝大多数RA患者经过早期、联合、个体化的规范治疗，预后良好。

Diagnostic and therapeutic progresses in rheumatoid arthritis

Rheumatoid arthritis(RA) is a common systemic autoimmune disease.There is neither specific diagnostic nor therapeutic approach for the disease,especially in atypical and uncommon cases.It has been known that autoantibodies such as AKA,APF,anti-RA33,anti-CCP and anti-Sa are valuable for the diagnosis of RA.New image techniques are more sensitive than conventional radiography.These serologic markers and image techniques dramatically improve the diagnosis of RA.At the same time,a number of novel biological agents have been clinically used.Studies have suggested that complete remission is achievable in most cases by early rational therapy.