| 含奈达铂与含顺铂联合化疗治疗中晚期卵巢上皮癌 |
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| 引用本文： | 吕靖,阚旋,英焕春,薛文. 含奈达铂与含顺铂联合化疗治疗中晚期卵巢上皮癌[J]. 实用药物与临床, 2009, 12(1) |
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| 作者姓名： | 吕靖 阚旋 英焕春 薛文 |
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| 作者单位： | 沈阳市第五人民医院肿瘤科,沈阳,110022;沈阳金贸医药集团,沈阳,110005;中国医科大学附属盛京医院妇产科,沈阳,110004;东丰县中医院放射科,吉林,东丰,136300 |
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| 摘 要： | 目的比较含奈达铂(NDP)与含顺铂(DDP)联合化疗方案治疗中晚期卵巢癌的疗效和不良反应。方法2004年1月至2007年12月收治中晚期卵巢癌患者60例,分别进入奈达铂+环磷酰胺或顺铂+环磷酰胺组,分析两组的近期疗效及毒副作用。结果奈达铂组与顺铂组的近期有效率分别为46.7%和53.5%,差异无统计学意义(P>0.05);奈达铂组白细胞减少的发生率(46.7%)低于顺铂组(73.3%),差异有统计学意义(P<0.05);奈达铂组血小板减少发生率(36.7%)高于顺铂组(26.7%),但差异无显著性差异(P>0.05);两组间贫血发生率相近,无显著性差异(P>0.05);奈达铂组胃肠道反应发生率(30%)低于顺铂组(56.7%),差异有统计学意义(P<0.05);奈达铂组1例患者(3.3%)出现肝功能损害,顺铂组未发现肝功能损害。两组均未出现肾功能损害病例。奈达铂组尿β2-MG异常发生率(16.7%)低于顺铂组(36.7%),差异有统计学意义(P<0.05)。结论奈达铂+环磷酰胺为中晚期卵巢癌的有效化疗方案。
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| 关 键 词： | 卵巢肿瘤 奈达铂 顺铂 联合化疗 |
Therapeutic effects of combination chemotherapy of nedaplatin and cisplatin on advanced ovarian cancer |
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| L Jing,KAN Xuan,YING Huan-chun,XUE Wen. Therapeutic effects of combination chemotherapy of nedaplatin and cisplatin on advanced ovarian cancer[J]. Practical Pharmacy and Clinical Remedies, 2009, 12(1) |
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| Authors: | L Jing KAN Xuan YING Huan-chun XUE Wen |
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| Affiliation: | 1.Department of Oncology;The Fifth Hospital of Shenyang;Shenyang 110023;China;2.Shenyang Jinmao Medical Group;Shenyang 110005;3.Department of Obstetrics and Gynecology;Shengjing Hospital of China Medical University;Shenyang 110004;4.Department of Radiology;Dongfeng County Hospital of Traditional Chinese Medicine;Dongfeng 136300;China |
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| Abstract: | Objective To compare the efficacy and safety of Nedaplatin(NDP)-based regimen with cisplatin(DDP)-based regimen on advanced ovarian cancer.Methods 60 patients with advanced ovarian cancer were given chemotherapy,nedaplatin+ cyclophos+ phamide or cisplatin+cyclophosphamide.The efficacy and side-effects of 2 groups were observed.Results The effective rate were 46.7% and 53.5% in nedaplatin group and cisplatin group(P>0.05).Leukopenia in nedaplatin group was weaker than that in cisplatin group(P<0.05),and the ... |
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| Keywords: | Ovarian neoplasms Nedaplatin Cisplatin Comprehensive chemotherapy |
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