乙脑患儿血浆和脑脊液中内皮素-1含量变化及其临床意义

目的 探讨内皮素（ET）与流行性乙型脑炎的关系。方法 采用放射免疫分析（RIA）法检测52例乙脑患儿血浆及脑脊液中内皮素-1（ET-1）含量。结果 乙脑患儿极期血浆及脑脊液中ET-1含量均明显高于对照组（P〈0．001），有显著统计学意义。重型乙脑患儿血浆及脑脊液中的ET-1含量均值明显高于普通型乙脑患儿（血浆P〈0．01，脑脊液P〈0．05）。结论 血浆及脑脊液中ET-1含量增高与脑实质损伤程度密切相关，其含量增高可作为脑实质损伤程度的一个重要指标。

The changes and clinical significance of Endothelin-1 in plasma and cerebrospinal fluid in children with epidemic encephalitis B

To study the relationship between endothelin-1(ET-1) and epidemic encephalitis B in children,the level of ET-1 in plasma and cerebrospinal fluid was measured in 52 patients with epidemic encephalitis B by using the radioimmunoassay(RIA).It was found that the level of ET-1 was significantly higher in epidemic encephalitis B than that of controls group(P<0.001).and the average value of severe type in the patients with epidemic encephalitis B was significantly higher than that of common type(plasma P<0.01,cerebrospinal fluid P<0.05).That is to say,the level of ET-1 is elevated in plasma and cerebrospinal fluid of epidemic encephalitis B and it is relate to the degree of parenchyrnal lesions of brain.These reseachs suggest that the elevation of ET-1 may be an important marker of the parenchymal lesions of brain in patients with epidemic encephalitis B.