颈椎后纵韧带骨化组织临床与病理分析

目的研讨颈椎后纵韧带骨化（OPLL）组织临床与病理学特点。方法留置并实验分析30例颈椎OPLL的骨化组织，行苏木素一伊红染色，显微镜观察形态及组织特点，结合临床进行分析。结果组织病理学检测中可见明显骨化演变过程：骨化区、钙化软骨区、纤维软骨区及纤维区。在后纵韧带深层或椎体后缘角出现小血管增生、韧带肥厚、软骨细胞增生、后纵韧带小钙化点及类软骨样细胞增生等组织病理学改变。结论后纵韧带骨化是一个延续过程，不同的骨化类型其演变过程不尽相同，病理学特点与临床特点相符。

Clinical and histopathological analysis of the ossified tissue Of posterior longitudinal ligament in the cervical spine

Objective To investigate and discuss clinical and histopathological characteristics of ossified tissues of the posterior longitudinal ligament （OPLL） in cervical spine. Methods We detained and empirically analyzed ossified tissues obtained from 30 patients with cervical OPLL. Hematoxylin-eosin dyeing was performed for all ossified tissues. Then we observed morphous and histological characteristics of these dyed ossified tissues by using microscope combined with clinical analysis. Results Histopathological experiments significantly showed the process of ossification： the ossified lesion developed from ossified zone, calcified cartilage zone, fibrocartilaginous zone and fibrous zone. Histopathological changes appeared in the deep layer of the posterior longitudinal ligament PLL or the trailing edge angle of vertebral body, such as proliferation of small vessel, hypertrophy of ligament, proliferation of cartilage cells, small calcified spots in PLL and proliferation of chondrocyte-like cells. Conclusions The process of the OPLL is continuous. There are some differences in different types of ossification. Histopathologieal characteristics corresponde with clinical ones.