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| 胃腺癌组织层粘连蛋白受体表达的意义 | |
| 引用本文： | 刘丽华,王士杰,单保恩,郝国桢,高建国,张召.胃腺癌组织层粘连蛋白受体表达的意义[J].世界华人消化杂志,2005,13(5):644-647. |
| 作者姓名： | 刘丽华 王士杰 单保恩 郝国桢 高建国 张召 |
| 作者单位： | 1. 承德医学院附属医院肿瘤科,河北省,承德市,067000 2. 河北省肿瘤研究所,河北省,石家庄市,050011 3. 河北医科大学第二医院内科,河北省,石家庄市,050000 |
| 摘 要： | |
| 关 键 词： | 胃腺癌 层粘连蛋白受体 免疫组化 |
| 修稿时间： | 2004年11月29 |
Expression and significance of laminin receptor in gastric adenocarcinoma |
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| Li-Hua Liu,Shi-Jie Wang,Bao-En Shan,Guo-Zhen Hao,Jian-Guo Gao,Zhao Zhang.Expression and significance of laminin receptor in gastric adenocarcinoma[J].World Chinese Journal of Digestology,2005,13(5):644-647. | |
| Authors: | Li-Hua Liu Shi-Jie Wang Bao-En Shan Guo-Zhen Hao Jian-Guo Gao Zhao Zhang |
| Institution: | Li-Hua Liu,Jian-Guo Gao,Zhao Zhang,Department of Oncology,the Affiliated Hospital of Chengde Medical College,Chengde 067000,China Shi-Jie Wang,Bao-En Shan,Hebei Cancer Institute,Shijiazhuang 050011,China Guo-Zhen Hao,Department of Internal Medicine,the Second Hospital of Hebei Medical University,Shijiazhuang 050000,China |
| Abstract: | AIM: To determine the expression of laminin receptor (LN-R) in gastric adenocarcinoma and its clinicopathological significance. METHODS: Immunohistochemical staining was performed on 76 cases of paraffin-embedded gastric adenocarcinoma tissues and 10 normal gastric mucosa tissues with mouse-anti-human LN-R polyclonal antibodies. RESULTS: The expression of LN-R in gastric adenocarcinoma was significantly higher than that in normal gastric mucosa tissues (P<0.05). The expression was significantly associated with differentiation degree, Bgrrmann stage, invasion depth, tumor size and lymphatic node metastasis (X2= 10.606, 9.979, 6.838, 7.611, 12.509, P<0.05). The positive expression was negatively correlated with the survival time (X2= 9.980, P<0.05). CONCLUSION: LN-R might act as an important index for judging the invasiveness, metastasis and prognosis of gastric adenocarcinoma. |
| Keywords: | Gastric adenocarcinoma Laminin receptor Immunohistochemistry |
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