| 多发腔隙性脑梗死与轻度认知功能障碍的关系 |
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| 引用本文： | 季芳,刘承延,石华英,祁小娟.多发腔隙性脑梗死与轻度认知功能障碍的关系[J].中国神经精神疾病杂志,2010,36(3). |
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| 作者姓名： | 季芳 刘承延 石华英 祁小娟 |
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| 作者单位： | 武汉科技大学附属天佑医院神经内科,武汉,430064 |
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| 摘 要： | 目的 探讨多发性腔隙性脑梗死(multiple lacunar infarction,MLI)对轻度认知功能损害(mild cognitive impairment,MCI)患者发展为痴呆的相关关系.方法 采用国际通用标准从门诊和住院患者中筛选轻度认知功能障碍患者.通过MRI和CT扫描,确定这些患者有否多发性腔隙性脑梗死.对轻度认知功能障碍患者进行随访,用Kapaln-Meier生存分析法评定MLI对MCI发展为痴呆的相关关系.结果 经临床和神经心理学评估,有120例MCI患者入选,其中43例(35.8%)经影像学诊断为伴有MLI,77例(64.1%)不伴MLI.经6～24个月随访,伴有MLI的患者有27(62.8%)例进展为痴呆,不伴MLI的患者有15例(19.4%)进展为痴呆.随访期内伴有MLI的MCI患者进展为痴呆的比例显著高于不伴MLI的患者(P＜0.05).结论 伴有MLI的MCI患者更容易进展为痴呆.这类MCI患者必须尽早进行干预,去除可控危险因素,预防痴呆发生.
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| 关 键 词： | 多发腔隙性脑梗死 轻度认知功能障碍 痴呆 |
The study on the relationship between multiple lacunar infarction and outcomes of mild Cognitive impairment |
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| JI Fang,LIU Chengyan,SHI Huaying,QI Xiaojuan.The study on the relationship between multiple lacunar infarction and outcomes of mild Cognitive impairment[J].Chinese Journal of Nervous and Mental Diseases,2010,36(3). |
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| Authors: | JI Fang LIU Chengyan SHI Huaying QI Xiaojuan |
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| Institution: | JI Fang,LIU Chengyan,SHI Huaying,QI Xiaojuan.Department of Neurology,the Affliated Hospital of Wuhan University of Science & Technology,Wuhan 430064,China |
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| Abstract: | Objective To evaluate the impact of multiple lacunar infarction(MLI)on the outcomes of mild cognitive impairment(MCI).Methods MCI patients were selected in outpatients and hospitalized patients using a common international standard MCI screen.Magnetic resonance imaging(MRI)and computer tomography(CT)were used to determine the presence of MLI.MCI patients were followed up for 6~24 months and their cognitive status and the impact of MLI on MCI were evaluated using Kaplan-Meier survival analysis.Results One hu... |
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| Keywords: | Lacunar Mild cognitive Impairment Dementia |
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