静脉滴注地尔硫革治疗不稳定型心绞痛疗效观察

目的观察地尔硫革针剂治疗不稳定型心绞痛的疗效及安全性。方法将30例经应用抗血小板、抗凝、改善血管内皮功能及抗心肌缺血等药物治疗后效果不佳的不稳定型心绞痛患者，给予静脉持续微量泵入地尔硫革72h治疗，从小剂量开始，依心绞痛发作情况、心率、血压、心功能等谨慎调整地尔硫革的剂量。观察治疗前后心绞痛发作次数、发作时持续时间、心电图ST—T波变化、心率、血压、心功能及肝肾功能等不良反应。结果静脉滴注地尔硫革治疗后，与治疗前比较，治疗后的平均心绞痛发作次数减少、每次发作持续时间缩短、发作时ST段压低程度减轻（只〈0．01）：治疗后血压、心率均明显降低（P〈0．01），心绞痛得到有效控制，总有效率93_3％。未发现严重不良反应。结论地尔硫革静脉泵入治疗难治性不稳定型心绞痛安全、有效。

Observation of curative effect of itravenous diltiazem in treatment of unstable angina

Objective To observe the curative effect of dihiazem in treatmeng of unstable angina pectoris. Methods A total of 30 unstable angina patients who failed to conventional anti-angina pectoris treatment, were treated with continuous infusion of intravenous dihiazem for 72 hours. The dose of dihiazem was revised from small dose according to angina attack frequency, heart rate, blood pressure and heart function. Angina attack frequency and the duration time of attacking, changes in ST-T wave, heart rate, blood pressure, heart function. Results The attack of angina was effectively controlled after dihiazem treatment compared with before diltizaem treatment. The average attack frequency and duration time and depression of ST segment were significantly decreased after diltizaem treatment（P 〈 0.01 ） The heart rate, blood pressure significantly decreased after diltizaem treatment （P 〈 0.01 ）, The total effective rate was 93.3%. without serious adverse reactions. Concousion It is effective and safe to teat unstable angina pectoris with diltizaem intravenous injection.