E-Cadherin、CD44v6在肾脏恶性肿瘤中的表达及意义 |
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引用本文: | 蒋悦.E-Cadherin、CD44v6在肾脏恶性肿瘤中的表达及意义[J].中国现代医生,2013,51(8):14-16. |
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作者姓名: | 蒋悦 |
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作者单位: | 蒋悦 (浙江省丽水市中心医院泌尿外科,浙江丽水,323000); |
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基金项目: | 浙江省丽水市公益性技术应用项目(项目编号:2012JYZB93) |
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摘 要: | 目的探讨E—Cadherin和CD44v6在。肾脏恶性肿瘤中的表达及临床意义。方法选择肾脏恶性肿瘤组织30例和正常肾组织10例,采用免疫组织化学法检测肾脏恶性肿瘤组织和正常肾组织中E—Cadherin、CD44v6的表达,比较两组之间的差异,并分析E—Cadherin和CD44v6与肾脏恶性肿瘤的临床分期、病理分级及淋巴结转移的关系。结果肾脏恶性肿瘤组织E—Cadherin表达显著低于对照组(P〈0.01),CD44v6表达显著高于对照组(-P〈0.05)。E—Cadherin表达在不同病理分级之间差异不显著(P〉0.05),CD44v6表达在不同病理分级之间差异显著(P〈0.01)。E—Cadherin、CD44v6表达在不同临床分期之间比较差异有统计学意义(P〈0.05):E—Cad—herin在有淋巴结转移的肾脏恶性肿瘤组织表达显著低于无淋巴结转移(P〈0.05)。结论E—Cadherin表达下调和CD44v6升高在肾脏恶性肿瘤的发生、发展、浸润等过程中发挥重要的作用。
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关 键 词: | 上皮钙黏附素 CD44基因含v6外显子的变异体 肾脏恶性肿瘤 |
Expression and its clinical effect of E-Cadherin, CD44v6 in renal carcinoma |
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Authors: | JIANG Yue |
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Institution: | JIANG Yue( Department of Urology, Lishui Central Hospital in Zhejiang Province, Lishui 323000, China) |
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Abstract: | Objective To discuss expression and clinical effect of E-Cadherin, CD44v6 in renal carcinoma. Methods Renal carcinoma tissue 30 cases and normal kidney tissue 10 cases were selected. Expression of E-Cadherin and CD44v6 in tissue were detected by immunohistochemistry method. The relationship of E-Cadherin and CD44v6 with renal carcinoma clinical stage, pathological grading and lymphatic metastasis were analyzed. Results Expression of ECadherin in renal carcinoma was obviously lower than in normal kidney (P 〈 0.01),and expression of CD44v6 in renal carcinoma was obviously higher than in normal kidney (P 〈 0.01). Expression of E-Cadherin in different pathological grading had no significant difference (P 〉 0.05), and expression of CD44v6 in different pathological grading had signif- icant difference (P 〈 0.01). Expression of E-Cadherin and CD44v6 in different clinical stage had significant difference (P 〈 0.05). Expression of E-Cadherin in cases with lymphatic metastasis was lower than without lymphatic metastasis (P 〈 0.05). Conclusion Decreasing of E-Cadherin expression and increasing of CD44v6 show important clinical effect in renal carcinoma happening, developing, infiltration. |
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Keywords: | E-Cadherin CD44v6 Renal carcinoma |
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