皮肌炎伴发肿瘤及死亡的临床分析

目的　探讨皮肌炎致死和伴发肿瘤的相关因素。方法　回顾性分析 1990年～ 2 0 0 3年皮肌炎患者的临床资料 ,分组后用 χ2 检验进行统计学分析。结果　年龄、Gottron丘疹、吞咽困难在皮肌炎伴发肿瘤中有显著意义 ;吞咽困难、声音嘶哑、饮水呛咳、肌肉萎缩、肺纤维化、心脏受累在导致皮肌炎 1年内死亡中有显著意义。结论　高龄、Gottron丘疹、吞咽困难预示皮肌炎伴发肿瘤的可能性大 ;吞咽困难、声音嘶哑、饮水呛咳、肌肉萎缩、肺纤维化、心脏受累提示皮肌炎预后不佳

Clinical Analysis of Malignancy and Death in Dermatomyositis

Objective To investigate the life-threatening factors of dermatomyositis(DM) complicated by neoplastic disease. Methods We retrospectively reviewed the clinical data of DM patients from 1990 to 2003.We performed univariate and multivariate analysis using chisquare test and logistic regression after dividing two groups.Results Age,Gottron papula and dysphagia of DM were related with the malignant tumors. Dysphagia,hoarsening,being choked when drinking,muscle atrophy,pulmonary interstitial fibrosis and heart involvement have remarkable significance in the life-threatening factors of DM during the first year after onset.Conclusion Advanced age,Gottron papula and dysphagia predicted that DM was complicated by malignant tumors.Dysphagia,hoarsening,being choked when drinking,muscle atrophy,pulmonary interstitial fibrosis and heart involvement predicted that DM had a poor prognosis.