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A quantitative and semi-automatic measurement of transverse sinus stenosis improves idiopathic intracranial hypertension diagnostic accuracy |
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| Authors: | A. Pellerin J. Aguilar Garcia A. David J. Meyer B. Guyomarch Delasalle S. De Gaalon E. Auffray Calvier H. Desal R. Bourcier |
| Affiliation: | 1. Department of Neuroradiology, centre hospitalier universitaire de Nantes, hôpital Laënnec, boulevard Jacques-Monod Saint-Herblain, 44093 Nantes cedex 1, France;2. Department of Radiology, centre hospitalier universitaire de Nantes, Hôtel-Dieu, 1, place Alexis-Ricordeau, 44093 Nantes cedex 1, France;3. Inserm UMR 1087/CNRS UMR 6291, l’institut du Thorax, boulevard Jacques Monod Saint-Herblain, 44093 Nantes cedex 1, France;4. Department of Neurology, centre hospitalier universitaire de Nantes, hôpital Laënnec, boulevard Jacques-Monod Saint-Herblain, 44093 Nantes cedex 1, France;5. Inserm UMR 1087/CNRS UMR 6291, l’institut du Thorax, IRS, Université de Nantes, 8, quai Moncousu, BP 70721, 44007 Nantes cedex 1, France |
| Abstract: | We propose a new reliable transverse sinus stenosis (TSS) index based on magnetic resonance venography (MRV) for the diagnosis of idiopathic intracranial hypertension (IIH). Our quantitative semi-automatic measurement analysis based on segmentation and cross-sectional TS diameter from 48 IIH patients and controls matched for age and sex, had a good inter-observer agreement (κ = 0.729) compared to a visual examination (κ = 0.467). A cut-off point ≥ 2 discriminate IIH patients from controls, with a sensitivity and specificity of 100%. |
| Keywords: | Venous stenosis Transverse sinus Magnetic resonance venography Idiopathic intracranial hypertension IIH idiopathic intracranial hypertension MRV magnetic resonance venography CSF cerebral spinal fluid TS transverse sinus TSS transverse sinus stenosis VSQS visual semi-quantitative scale QSAM quantitative semi-automatic measurement MITSS multiplicative index of TSS BMI body mass index ROC receiver operating curve AUC area under curve |
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