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Hydralazine-associated Amenorrhea in a Premenopausal Patient With Chronic Kidney Disease: A Case Report and Review of Literature
Authors:Kwadwo A. Yeboah  Amy Allspaw  Akram Al-Makki  Brian M. Shepler
Affiliation:1. College of Pharmacy, Purdue University, West Lafayette, Indiana;2. Indiana University Health Arnett, West Lafayette, Indiana
Abstract:

Purpose

Several antihypertensive medications have been associated with various forms of sexual dysfunction. We present a case report of a premenopausal patient with hydralazine-associated amenorrhea.

Methods

The Naranjo adverse drug reaction probability scale was used to assess causality. We also performed a literature search on PubMed to find publications that report hydralazine-associated amenorrhea.

Results

The Naranjo scale generated a score of 6, suggesting a probable relationship between amenorrhea and hydralazine therapy. No publications associating hydralazine with amenorrhea were identified.

Implications

A probable relationship exists between hydralazine and the development of amenorrhea.
Keywords:amenorrhea  hydralazine  hypertension  vasodilators
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