复方制剂珮夫人小儿咳露中主药成分的含量测定

目的 :建立一种采用高效液相色谱检测复方制剂中氢溴酸美沙芬、愈创木酚甘油醚和马来酸氯苯那敏含量的方法。方法 :采用C1 8色谱柱 ,以 0 .0 0 2 5mol·L- 1 IPR -B6 甲醇溶液∶水 (含 2 %三乙胺 )∶磷酸 (12 0∶10 0∶1)为流动相 ,检测波长为 2 5 7nm。结果 :氢溴酸美沙芬、愈创木酚甘油醚和马来酸氯苯那敏 3种成分的回收率分别为10 0 .5 % ,99.5 % ,10 0 .6% ;RSD分别为 2 .2 % ,1.6% ,1.9% (n =7)。结论 :本方法简便 ,结果准确可靠

DETERMINATION FOR THE CONTENTS OF THREE ACTIVE INGREDIENTS IN MADAME PEARL''''S COUGH SYRUP FOR CHILDREN

Objective : A method of HPLC for the determination of complex preparations of guaiphenesin , chlorpheniramine maleate and dextromethorphan hydrobromide has been described Methods : C 18 column , 0.0025 mol·L -1 IPR-B 6 in methanol ∶ water ( containing 2% triethylamine )∶ phosphate acid (120∶100∶1) as the mobile phase were adopted The wavelength of detectionwas 257 nm. Results : The method recoveries of guaiphenesin , chlorpheniramine maleate and dextromethorphan hydrobromide were 99.5%, 100.6% and 100.5%, respectively . RSD were 1.6%, 1.9% and 2.2 ( n =7),respectively . Conclusion: The method is simple , rapid and reliable .