牛磺酸对大鼠慢性缺氧性肺动脉高压的预防作用

目的：进一步研究牛磺酸对慢性缺氧性肺动脉高压的防治作用。方法：复制大鼠间断缺氧４周模型，采用透射电镜、放射免疫和生化技术研究牛磺酸对肺动脉高压的治疗效果。结果：缺氧４周大鼠肺动脉压力升高，右心肥大，血中ＥＴ－１、ＡＣＥ水平升高，ＮＯ－２／ＮＯ－３和ＳＯＤ水平降低；ＭＰＡＰ与ＥＴ－１呈正相关，与ＮＯ－２／ＮＯ－３呈负相关；牛磺酸可抑制缺氧大鼠ＥＴ－１和ＡＣＥ分泌，增加ＮＯ和ＳＯＤ水平，降低肺动脉压力；透射电镜观察表明牛磺酸能对抗缺氧大鼠的心肺组织损伤。结论：牛磺酸通过减轻缺氧所致细胞损伤，调节血管舒缩物质的平衡，对缺氧性肺高压有一定防治作用。

The preventive effects of taurine on chronic hypoxic pulmonary hypertension in rats

AIM: To study the preventive effect of taurine on chronic hypoxic pulmonary hypertension (PH). METHODS:Transmission electron microscope, radioimmunoassay and biochemical analysis were used to assay the role of taurine. RESULTS:The mean pulmonary arterial pressure, the concentration of plasma endothelin-1(ET-1) and the angiotensin converting enzyme (ACE) were significantly higher in the hypoxic rat than that in control animals. The contents of blood nitric oxide (NO) and superoxide dismutase (SOD) were significantly lower in the hypoxic rat than that in control animals. Taurine reduced the release of ET-1 and ACE, increased the level of NO and SOD. Ultrastructural examination revealed that the injuries of the ultrastructure of heart and lung in rat with PH were improved obviously by pretreatment with taurine.CONCLUSION:The taurine could protect and extenuate hypoxia-induced injuries of cells, regulate the balance of vasomotor factors under hypoxic condition. The taurine could effectively prevent and treat the chronic hypoxic PH.